PMID- 9013863
OWN - NLM
STAT- MEDLINE
DCOM- 19970220
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 402
IP  - 1
DP  - 1997 Jan 27
TI  - The cloning and characterization of human MyD88: a member of an IL-1 receptor 
      related family.
PG  - 81-4
AB  - Murine MyD88, an RNA with homology both to the interleukin-1 receptor signaling 
      domain and to 'death-domains', is rapidly upregulated during differentiation of 
      the myeloleukemic cell line M1. We have cloned the human homologue of murine 
      MyD88 and re-evaluated the murine sequence. The open reading frame for both 
      species encodes a 296 amino acid protein, which for murine MyD88 is 53 amino 
      acids longer than originally published. Human MyD88 cDNA is encoded by 5 exons, 
      and maps to chromosome 3p21.3-p22 by fluorescence in situ hybridization (FISH). 
      Overexpression of the death domain region leads to transcriptional activation of 
      the IL-8 promoter.
FAU - Bonnert, T P
AU  - Bonnert TP
AD  - Immunex Corporation, Seattle, WA 98101, USA. tim_bonnert@merck.com
FAU - Garka, K E
AU  - Garka KE
FAU - Parnet, P
AU  - Parnet P
FAU - Sonoda, G
AU  - Sonoda G
FAU - Testa, J R
AU  - Testa JR
FAU - Sims, J E
AU  - Sims JE
LA  - eng
SI  - GENBANK/U84408
SI  - GENBANK/U84409
PT  - Journal Article
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (DNA, Complementary)
RN  - 0 (Interleukin-8)
RN  - 0 (MYD88 protein, human)
RN  - 0 (Myd88 protein, mouse)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Interleukin-1)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Antigens, Differentiation
MH  - Base Sequence
MH  - COS Cells
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 3
MH  - DNA, Complementary/genetics
MH  - Exons
MH  - Gene Expression
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Interleukin-8/genetics
MH  - Introns
MH  - Mice
MH  - Molecular Sequence Data
MH  - Myeloid Differentiation Factor 88
MH  - Oligonucleotides, Antisense
MH  - Promoter Regions, Genetic
MH  - Proteins/chemistry/*genetics
MH  - RNA, Messenger/genetics
MH  - *Receptors, Immunologic
MH  - Receptors, Interleukin-1/chemistry/genetics
MH  - Transfection
EDAT- 1997/01/27 00:00
MHDA- 1997/01/27 00:01
CRDT- 1997/01/27 00:00
PHST- 1997/01/27 00:00 [pubmed]
PHST- 1997/01/27 00:01 [medline]
PHST- 1997/01/27 00:00 [entrez]
AID - S0014-5793(96)01506-2 [pii]
AID - 10.1016/s0014-5793(96)01506-2 [doi]
PST - ppublish
SO  - FEBS Lett. 1997 Jan 27;402(1):81-4. doi: 10.1016/s0014-5793(96)01506-2.