PMID- 9014852
OWN - NLM
STAT- MEDLINE
DCOM- 19970220
LR  - 20190709
IS  - 0022-0795 (Print)
IS  - 0022-0795 (Linking)
VI  - 152
IP  - 1
DP  - 1997 Jan
TI  - Maternal diabetes induces upregulation of hepatic insulin-like growth factor 
      binding protein-1 MRNA expression, growth retardation and developmental delay at 
      the same stage of rat fetal development.
PG  - R1-6
AB  - Since maternal diabetes is associated with fetal growth abnormalities in humans 
      and rats, effects of maternal diabetes on fetal expression of genes regulating 
      growth are of interest. Increased expression of Insulin-Like Growth Factor 
      Binding Protein-I (IGFBP-1) is associated with several examples of growth 
      retardation and is upregulated in response to diabetes. As we have shown 
      previously, IGFBP-1 expression is upregulated in gestational day (GD) 14 rat 
      fetuses in response to maternal diabetes. Here we analyze the effect of 
      streptozotocin-induced maternal diabetes on IGFBP-1 mRNA expression during 
      GD12-16 of rat fetal development, using in situ hybridization. IGFBP-1 mRNA was 
      more abundant in GD12-14 fetal livers from diabetic dams than in livers of 
      age-matched controls. This upregulation is not due to the approximately 1-day 
      fetal developmental delay associated with maternal diabetes, as there is no gross 
      difference in the level of IGFBP-1 mRNA in GD13 vs GD12 or GD14 vs GD13 control 
      fetal livers. At GD15-16, however, we detected little difference in IGFBP-1 
      expression between experimental and control fetuses. This transient period of 
      maternal diabetes-stimulated IGFBP-1 mRNA expression (GD12-14) is coincident with 
      the sensitive period for maternal diabetes-induced defects in fetal growth and 
      development, suggesting that IGFBP-1 is involved in the regulation of fetal 
      growth and development in response to the maternal condition.
FAU - Rajaratnam, V S
AU  - Rajaratnam VS
AD  - Food and Drug Administration, Department of Health and Human Services, Jefferson, 
      AR 72079, USA.
FAU - Webb, P J
AU  - Webb PJ
FAU - Fishman, R B
AU  - Fishman RB
FAU - Streck, R D
AU  - Streck RD
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Endocrinol
JT  - The Journal of endocrinology
JID - 0375363
RN  - 0 (Insulin-Like Growth Factor Binding Protein 1)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Experimental/*metabolism
MH  - Embryonic and Fetal Development
MH  - Female
MH  - Fetal Growth Retardation/*metabolism
MH  - Gene Expression Regulation
MH  - Gestational Age
MH  - In Situ Hybridization
MH  - Insulin-Like Growth Factor Binding Protein 1/*genetics
MH  - Liver/embryology/*metabolism
MH  - Pregnancy
MH  - Pregnancy in Diabetics/*metabolism
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1677/joe.0.152r001 [doi]
PST - ppublish
SO  - J Endocrinol. 1997 Jan;152(1):R1-6. doi: 10.1677/joe.0.152r001.