PMID- 9014859
OWN - NLM
STAT- MEDLINE
DCOM- 19970220
LR  - 20091119
IS  - 0022-3417 (Print)
IS  - 0022-3417 (Linking)
VI  - 180
IP  - 4
DP  - 1996 Dec
TI  - Immunoreactivity for hepatocyte growth factor/scatter factor and its receptor, 
      met, in human lung carcinomas and malignant mesotheliomas.
PG  - 389-94
AB  - Paraffin sections from 29 lung carcinomas (28 primary and 1 metastatic) and 9 
      pleural malignant mesotheliomas were immunostained with antisera to human 
      hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, met. For 
      HGF/SF, immunoreactivity was demonstrated in all 9 mesotheliomas, 9 of 12 
      adenocarcinomas, and 7 of 10 squamous cell carcinomas. None of seven cases of 
      small cell anaplastic carcinoma was positive. The adenocarcinomas frequently 
      showed enhanced luminal staining, suggesting possible secretion of HGF/SF, and 
      this pattern of staining was also seen occasionally in bronchial epithelium 
      adjacent to the tumour. Stromal fibroblasts also showed immunoreactivity for 
      HGF/SF in 6/8 cases of mesothelioma but in only 3/12 adenocarcinomas, 1/10 
      squamous cell carcinomas, and 1/4 small cell anaplastic carcinomas. All tumours 
      stained for met, usually strongly. The staining was mainly cytoplasmic in nature, 
      but some plasma membrane staining was usually evident. Adenocarcinomas showed 
      strong luminal membrane staining, as did adjacent, histologically normal 
      bronchial epithelium. This study demonstrates the presence of HGF/SF and met in 
      most of the tumour types described, particularly mesotheliomas, and suggests that 
      the HGF/SF/met signalling system may play a role in the development of these 
      tumours, either by autocrine or by paracrine mechanisms.
FAU - Harvey, P
AU  - Harvey P
AD  - School of Biology, University of East Anglia, Norwich NR4 7TJ, UK.
FAU - Warn, A
AU  - Warn A
FAU - Newman, P
AU  - Newman P
FAU - Perry, L J
AU  - Perry LJ
FAU - Ball, R Y
AU  - Ball RY
FAU - Warn, R M
AU  - Warn RM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
RN  - 0 (Neoplasm Proteins)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Aged
MH  - Female
MH  - Hepatocyte Growth Factor/*metabolism
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Lung Neoplasms/*metabolism
MH  - Male
MH  - Mesothelioma/*metabolism
MH  - Middle Aged
MH  - Neoplasm Proteins/metabolism
MH  - Pleural Neoplasms/*metabolism
MH  - Proto-Oncogene Proteins c-met
MH  - Receptor Protein-Tyrosine Kinases/*metabolism
EDAT- 1996/12/01 00:00
MHDA- 2000/06/20 09:00
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - 10.1002/(SICI)1096-9896(199612)180:4<389::AID-PATH685>3.0.CO;2-K [pii]
AID - 10.1002/(SICI)1096-9896(199612)180:4<389::AID-PATH685>3.0.CO;2-K [doi]
PST - ppublish
SO  - J Pathol. 1996 Dec;180(4):389-94. doi: 
      10.1002/(SICI)1096-9896(199612)180:4<389::AID-PATH685>3.0.CO;2-K.