PMID- 9015145
OWN - NLM
STAT- MEDLINE
DCOM- 19970227
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 372
IP  - 2
DP  - 1996 Dec
TI  - Evidence for a parent-of-origin effect on sperm aneuploidy in mice carrying 
      Robertsonian translocations as analyzed by fluorescence in situ hybridization.
PG  - 269-78
AB  - Multi-color fluorescence in situ hybridization (FISH) was employed to investigate 
      variations in the frequency of aneuploid spermatids produced by males derived 
      from three separate lines of Robertsonian translocations in mice: Rb(2.8)2Lub, 
      Rb(8.12)22Lub, and Rb(8.14)16Rma, each with one arm involving chromosome 8. The 
      DNA probes used were specific for repetitive sequences on chromosomes 8 and X. 
      Heterozygous males for these Robertsonian translocations produced approximately 
      1% of spermatids with hyperhaploid for chromosome 8. which was > 80 times higher 
      than the frequency of sperm hyperhaploid for chromosome X within the same 
      animals; consistent elevations in chromosome-8 sperm disomy were observed among 
      lines. In addition, approximately 25% higher fractions of sperm aneuploidy were 
      observed when the Robertsonian translocation was inherited from the father rather 
      than from the mother (p = 0.009). These findings illustrate the sensitivity of 
      the FISH procedure for detecting small differences in the hyperhaploidy in male 
      germ cells and suggest that imprinted factors may influence sperm aneuploidy.
FAU - Baulch, J E
AU  - Baulch JE
AD  - Biology and Biotechnology Research Program, Lawrence Livermore National 
      Laboratory, Livermore, CA 94550, USA.
FAU - Lowe, X R
AU  - Lowe XR
FAU - Bishop, J B
AU  - Bishop JB
FAU - Wyrobek, A J
AU  - Wyrobek AJ
LA  - eng
GR  - Y01-ES-10203-00/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
SB  - IM
MH  - *Aneuploidy
MH  - Animals
MH  - Chimera
MH  - Female
MH  - Heterozygote
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Male
MH  - Mice
MH  - Spermatids/*physiology
MH  - Translocation, Genetic/*genetics
MH  - X Chromosome/genetics
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - S0027510796001467 [pii]
AID - 10.1016/s0027-5107(96)00146-7 [doi]
PST - ppublish
SO  - Mutat Res. 1996 Dec;372(2):269-78. doi: 10.1016/s0027-5107(96)00146-7.