PMID- 9017890
OWN - NLM
STAT- MEDLINE
DCOM- 19970404
LR  - 20041117
IS  - 0043-5325 (Print)
IS  - 0043-5325 (Linking)
VI  - 108
IP  - 24
DP  - 1996 Dec 27
TI  - Autoimmune reactions in patients with silicone breast implants.
PG  - 781-7
AB  - Silicone breast implants have been surgical routine for over 30 years. An 
      association between silicone augmentation and immune related diseases has been 
      reported in approximately 100 cases. In a retrospective single center study we 
      investigated 36 non-selected women with silicone breast implants and 36 sex- and 
      age-matched controls. Autoimmune reactions were evaluated by measuring 
      antinuclear antibodies (ANA), rheumatoid factor (RF) and thyroid gland antibodies 
      (TMS), along with angiotensin-converting enzyme (ACE), C-reactive protein (CRP) 
      and other immunological and laboratory parameters. In the controls only 3 (8%) 
      women had an elevated ANA titer and 1 demonstrated thyroid autoantibodies 
      (microsomal), giving a total of 4 (11%) women with detectable autoantibodies. By 
      contrast, 12 (33%) of the 36 women with silicone augmentation had raised ANA 
      titers (> or = 1 : 80), a significantly higher percentage than in the control 
      group (p < 0.02). Of the 12 women, 1 showed antismooth muscle antibodies (ASMA; 
      titer 1 : 40) and 2 of the patients displayed antineutrophilic cytoplasm 
      antibodies (ANCA; 1 : 320 and 1 : 40, respectively), one of the latter also being 
      positive for rheumatoid factor. 2 further women demonstrated thyroid 
      autoantibodies (microsomal), giving a total of 14 (39%) women in whom significant 
      autoantibodies were detectable. Clinical symptoms (musculoskeletal) were present 
      in 1 patient. Most of the observed autoantibodies were organ-unspecific, with a 
      predominance of elevated ANA titers of the heterogeneous type and not related to 
      a distinct clinical entity. However, none of the investigated women with silicone 
      breast implants showed clinical symptoms or signs of connective tissue disease 
      according to ARA criteria.
FAU - Zazgornik, J
AU  - Zazgornik J
AD  - II. Department of Medicine, General Hospital Linz.
FAU - Piza, H
AU  - Piza H
FAU - Kaiser, W
AU  - Kaiser W
FAU - Bettelheim, P
AU  - Bettelheim P
FAU - Steiner, G
AU  - Steiner G
FAU - Smolen, J
AU  - Smolen J
FAU - Biesenbach, G
AU  - Biesenbach G
FAU - Maschek, W
AU  - Maschek W
LA  - eng
PT  - Journal Article
PL  - Austria
TA  - Wien Klin Wochenschr
JT  - Wiener klinische Wochenschrift
JID - 21620870R
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Autoantibodies)
RN  - 0 (Silicones)
SB  - IM
CIN - Wien Klin Wochenschr. 1996 Dec 27;108(24):773-4. PMID: 9092209
MH  - Acute-Phase Proteins/metabolism
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Austria
MH  - Autoantibodies/blood
MH  - Autoimmune Diseases/*chemically induced/immunology
MH  - *Breast Implants
MH  - Female
MH  - Humans
MH  - *Mammaplasty
MH  - Middle Aged
MH  - Organ Specificity/immunology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Silicones/*adverse effects
EDAT- 1996/12/27 00:00
MHDA- 1996/12/27 00:01
CRDT- 1996/12/27 00:00
PHST- 1996/12/27 00:00 [pubmed]
PHST- 1996/12/27 00:01 [medline]
PHST- 1996/12/27 00:00 [entrez]
PST - ppublish
SO  - Wien Klin Wochenschr. 1996 Dec 27;108(24):781-7.