PMID- 9020960
OWN - NLM
STAT- MEDLINE
DCOM- 19970225
LR  - 20190909
IS  - 0955-3002 (Print)
IS  - 0955-3002 (Linking)
VI  - 71
IP  - 1
DP  - 1997 Jan
TI  - A rapid method for measuring pericentric inversions using fluorescence in situ 
      hybridization (FISH).
PG  - 29-33
AB  - We used three common fluorescent probes to measure pericentric inversion 
      frequencies in 2.9 Gy 60Co gamma-irradiated human lymphocytes. For a given 
      chromosome, the first probe is specific to one telomeric region, the second probe 
      is specific to one subcentromeric region and the third probe is specific to the 
      centromere. A pericentric inversion is made observable by the change in position 
      (switching) of the fluorescent signals relative to the chromosome centromere. Our 
      data showed equality between pericentric inversions and centric rings. The 
      calculated whole-genome F-ratio of apparently simple translocations to 
      pericentric inversions was 5.6.
FAU - Lucas, J N
AU  - Lucas JN
AD  - Lawrence Livermore National Laboratory, University of California, Livermore 
      94551, USA.
FAU - Hill, F S
AU  - Hill FS
FAU - Chen, A M
AU  - Chen AM
FAU - Burk, C E
AU  - Burk CE
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
SB  - IM
MH  - Animals
MH  - Chromosome Banding
MH  - *Chromosome Inversion
MH  - Dogs
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Lymphocytes/radiation effects
MH  - Translocation, Genetic
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1080/095530097144382 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 1997 Jan;71(1):29-33. doi: 10.1080/095530097144382.