PMID- 9021679
OWN - NLM
STAT- MEDLINE
DCOM- 19970529
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 23
IP  - 1-2
DP  - 1996 Sep
TI  - The graft-versus-leukemia effect of post-transplant donor leukocyte infusion.
PG  - 1-9
AB  - Tumor relapse remains a major obstacle to the success of allogeneic bone marrow 
      transplantation (BMT) as a treatment for leukemia. Due to limited treatment 
      options, the outlook for most patients that relapse following allogeneic BMT has 
      been poor. The infusion of normal immunocompetent leukocytes from the original 
      marrow donor has become a promising new option for treating/preventing leukemia 
      relapse in allogeneic BMT recipients. This form of treatment has often been 
      referred to as donor leukocyte infusion (DLI) therapy. Our laboratory is using 
      murine models of allogeneic BMT to address important unresolved issues regarding 
      DLI therapy in an effort to make the treatment more effective. These include 
      identification of the antileukemic effector cells, augmentation of the 
      antileukemic effect, and understanding why graft-versus-host-disease (GVHD) is 
      less severe than anticipated. This article reviews our work in murine models of 
      DLI and introduces our current working hypotheses concerning DLI therapy.
FAU - Johnson, B D
AU  - Johnson BD
AD  - Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA.
FAU - Hanke, C A
AU  - Hanke CA
FAU - Truitt, R L
AU  - Truitt RL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
SB  - IM
MH  - Animals
MH  - *Blood Donors
MH  - Bone Marrow Transplantation/*adverse effects/immunology
MH  - Combined Modality Therapy
MH  - Graft vs Host Disease/*immunology
MH  - Humans
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/immunology/*therapy
MH  - *Leukocyte Transfusion
MH  - Mice
MH  - Recurrence
MH  - Transplantation, Homologous
RF  - 65
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
AID - 10.3109/10428199609054795 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 1996 Sep;23(1-2):1-9. doi: 10.3109/10428199609054795.