PMID- 9021815
OWN - NLM
STAT- MEDLINE
DCOM- 19970415
LR  - 20191024
IS  - 0888-0018 (Print)
IS  - 0888-0018 (Linking)
VI  - 14
IP  - 1
DP  - 1997 Jan-Feb
TI  - Bone marrow transplantation in patients with Fanconi anemia: experience with 
      cyclophosphamide and total body irradiation conditioning regimen.
PG  - 67-72
AB  - Eleven patients with Fanconi anemia (FA) underwent bone marrow transplantation 
      (BMT) between March 1985 and May 1990 in a single institution. Ten patients 
      received bone marrow from healthy full human leukocyte antigen (HLA) matched 
      siblings and one patient from her father (one antigen mismatch). Ten patients 
      were conditioned with cyclophosphamide (Cy) at a dose of 5 mg/kg per day for 4 
      days followed by total body irradiation (TBI) for a total of 600 cGy over 3 days. 
      Six of the 11 patients are alive and have normal reconstitution of their bone 
      marrow. Median follow-up was 72 months (range 42-84). Three of the 10 patients 
      who received Cy and TBI (two HLA compatible, one antigen mismatch) had graft 
      failure. Five patients developed at least grade III acute graft-versus-host 
      disease (GVHD). The rates of graft failure and GVHD are, however, still 
      significantly high. Modification of the conditioning regimen and GVHD prophylaxis 
      is needed to improve the outcome.
FAU - Solh, H
AU  - Solh H
AD  - Department of Oncology, King Faisal Specialist Hospital and Research Centre, 
      Riyadh, Saudi Arabia.
FAU - Rao, K
AU  - Rao K
FAU - Martins da Cunha, A M
AU  - Martins da Cunha AM
FAU - Padmos, A
AU  - Padmos A
FAU - Sackey, K
AU  - Sackey K
FAU - Ernst, P
AU  - Ernst P
FAU - Spence, D
AU  - Spence D
FAU - Clink, H
AU  - Clink H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pediatr Hematol Oncol
JT  - Pediatric hematology and oncology
JID - 8700164
RN  - 0 (Immunosuppressive Agents)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Adolescent
MH  - *Bone Marrow Transplantation
MH  - Child
MH  - Child, Preschool
MH  - Cyclophosphamide/*therapeutic use
MH  - Fanconi Anemia/*therapy
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Male
MH  - Retrospective Studies
MH  - Transplantation Conditioning/*methods
MH  - Treatment Outcome
MH  - *Whole-Body Irradiation
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.3109/08880019709030886 [doi]
PST - ppublish
SO  - Pediatr Hematol Oncol. 1997 Jan-Feb;14(1):67-72. doi: 10.3109/08880019709030886.