PMID- 9022057
OWN - NLM
STAT- MEDLINE
DCOM- 19970306
LR  - 20071115
IS  - 1058-8388 (Print)
IS  - 1058-8388 (Linking)
VI  - 208
IP  - 2
DP  - 1997 Feb
TI  - Differential expression of transcripts encoding retinoid binding proteins and 
      retinoic acid receptors during placentation of the mouse.
PG  - 199-210
AB  - We report the distribution of transcripts from genes encoding the retinol binding 
      protein (RBP), the cellular retinol binding proteins (CRBP I, II) and retinoic 
      acid binding proteins (CRABP I, II), the retinaldehyde dehydrogenase type 2 
      (RALDH-2), the retinoic acid receptors (RARs), and the retinoid X receptors 
      (RXRs) in mouse placental tissues from 6.5 to 19.5 days postcoitum (dpc). During 
      early placentation, RBP and RALDH-2 gene expression are restricted to the 
      endoderm of the visceral yolk sac and the outer uterine epithelium, respectively, 
      whereas CRBP I transcripts are detected in the visceral yolk sac and in the 
      presumptive chorioallantoic placenta. By 15.5 dpc, CRBP I expression is 
      down-regulated in the yolk sac where CRBP II becomes strongly expressed. 
      Expression of CRBP II is also detected in the trophoblastic giant cells. 
      Throughout placentation, the expression patterns of the CRABP I and II genes 
      partly overlap in the decidual tissue and the vacuolar zones of the decidua, 
      suggesting a role for these binding proteins in sequestering free retinoic acid 
      from maternal blood, thus regulating its availability to the embryo. RAR alpha is 
      ubiquitously expressed in all placental tissues, except in trophoblastic giant 
      cells, at all stages studied. During early placentation, RAR beta and RAR gamma 
      are co-expressed in the decidua but differentially expressed in the chorionic 
      region (RAR beta, 10.5 to 12.5 dpc) and the presumptive labyrinth (RAR gamma, 7.5 
      to 12.5 dpc). During the same stages, RXR alpha is strongly expressed in the 
      presumptive placenta. RAR gamma remains weakly expressed in the labyrinth until 
      15.5 dpc, whereas RXR alpha exhibits a strong expression in this zone until 
      birth, suggesting a role for these receptors in the development and function of 
      the definitive placenta.
FAU - Sapin, V
AU  - Sapin V
AD  - Institut de Genetique et de Biologie Moleculaire et Cellulaire, 
      CNRS/INSERM/ULP/College de France, C.U. de Strasbourg, Illkirch, France.
FAU - Ward, S J
AU  - Ward SJ
FAU - Bronner, S
AU  - Bronner S
FAU - Chambon, P
AU  - Chambon P
FAU - Dolle, P
AU  - Dolle P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Dyn
JT  - Developmental dynamics : an official publication of the American Association of 
      Anatomists
JID - 9201927
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinol-Binding Proteins)
RN  - 0 (Retinol-Binding Proteins, Cellular)
RN  - 0 (retinoic acid binding protein I, cellular)
RN  - 0 (retinoic acid binding protein II, cellular)
SB  - IM
MH  - Animals
MH  - Female
MH  - Gene Expression Regulation, Developmental
MH  - Mice
MH  - Placentation/*physiology
MH  - Pregnancy
MH  - Receptors, Retinoic Acid/*genetics
MH  - Retinol-Binding Proteins/*genetics
MH  - Retinol-Binding Proteins, Cellular
MH  - Time Factors
MH  - Transcription, Genetic
EDAT- 1997/02/01 00:00
MHDA- 2000/06/22 10:00
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 2000/06/22 10:00 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.1002/(SICI)1097-0177(199702)208:2<199::AID-AJA7>3.0.CO;2-D [pii]
AID - 10.1002/(SICI)1097-0177(199702)208:2<199::AID-AJA7>3.0.CO;2-D [doi]
PST - ppublish
SO  - Dev Dyn. 1997 Feb;208(2):199-210. doi: 
      10.1002/(SICI)1097-0177(199702)208:2<199::AID-AJA7>3.0.CO;2-D.