PMID- 9022274
OWN - NLM
STAT- MEDLINE
DCOM- 19970304
LR  - 20190831
IS  - 0379-0738 (Print)
IS  - 0379-0738 (Linking)
VI  - 83
IP  - 2
DP  - 1996 Dec 2
TI  - Distribution of 3,4-methylenedioxymethamphetamine (MDMA) and 
      3,4-methylenedioxyamphetamine (MDA) stereoisomers in a fatal poisoning.
PG  - 111-9
AB  - This communication presents the quantitation and differential distribution of the 
      enantiomers of 3,4-methylenedioxymethamphetamine (MDMA) and its physiologically 
      active metabolite 3,4-methylenedioxyamphetamine (MDA) in a fatal poisoning 
      following insufflation of MDMA, cocaine and heroin. Animal studies have 
      demonstrated the stereoselective pharmacokinetics and neurotoxicity of these 
      compounds; however, enantiomeric distributions have not been reported in humans. 
      Quantitation of MDMA and MDA enantiomer was by gas chromatography/mass 
      spectrometry (GC/MS) following chiral derivatization with 
      N-trifluoroacetyl-L-triproyl chloride (LTPC). The decedents' blood concentration 
      of S(+)-MDMA was slightly less than that of R(-)-MDMA (1.3 vs. 1.6 mg/l, 
      respectively), while the S(+)- and R(-)-MDA blood concentrations were identical 
      (0.8 mg/l). Both primary routes of excretion, bile and urine, had greater 
      concentrations of R(-)-MDMA than the S(+) isomer. These fluids also contained 
      twice the concentration of S(+)-MDA than the R(-)-isomer. These data indicate 
      that S(+)-MDMA is metabolized and eliminated faster than R(-)-MDMA. The results 
      appear to support the findings in animals regarding stereoselective metabolism of 
      MDMA.
FAU - Moore, K A
AU  - Moore KA
AD  - Department of Pathology, Medical College of Virginia, Virginia 23298-0165, USA.
FAU - Mozayani, A
AU  - Mozayani A
FAU - Fierro, M F
AU  - Fierro MF
FAU - Poklis, A
AU  - Poklis A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (Narcotics)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 70D95007SX (Heroin)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/pharmacokinetics
MH  - Adult
MH  - Cocaine/poisoning
MH  - Fatal Outcome
MH  - Gas Chromatography-Mass Spectrometry
MH  - Heroin/poisoning
MH  - Humans
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/blood/*pharmacokinetics/*poisoning
MH  - Narcotics/poisoning
MH  - Stereoisomerism
MH  - Tissue Distribution
RF  - 28
EDAT- 1996/12/02 00:00
MHDA- 1996/12/02 00:01
CRDT- 1996/12/02 00:00
PHST- 1996/12/02 00:00 [pubmed]
PHST- 1996/12/02 00:01 [medline]
PHST- 1996/12/02 00:00 [entrez]
AID - S0379-0738(96)02025-7 [pii]
AID - 10.1016/s0379-0738(96)02025-7 [doi]
PST - ppublish
SO  - Forensic Sci Int. 1996 Dec 2;83(2):111-9. doi: 10.1016/s0379-0738(96)02025-7.