PMID- 9023310
OWN - NLM
STAT- MEDLINE
DCOM- 19970317
LR  - 20131121
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 280
IP  - 2
DP  - 1997 Feb
TI  - Nitric oxide and the neurotoxic effects of methamphetamine and 
      3,4-methylenedioxymethamphetamine.
PG  - 941-7
AB  - The role of nitric oxide (NO) in the long-term, amine-depleting effects of 
      methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA) was 
      investigated in the rodent central nervous system. The NO synthase inhibitor 
      N(G)-nitro-L-arginine methyl ester (L-NAME) antagonized the dopamine- and 
      serotonin-depleting effects of both METH and MDMA. The protective actions of 
      L-NAME in METH-treated mice were reversed by prior administration of the NO 
      generator isosorbide dinitrate. However, pretreatment with 
      N(G)-monomethyl-L-arginine or N(G)-nitro-L-arginine, two other NO synthase 
      inhibitors, failed to block the neurotoxic effects of METH or MDMA. L-NAME was 
      also the only NO synthase inhibitor that antagonized the hyperthermic effects of 
      METH, reducing colonic temperatures in mice by a mean of 3 degrees C, in 
      comparison with control. Moreover, if the hypothermic effects of L-NAME in 
      METH-treated mice were prevented by raising the ambient room temperature, the 
      dopamine-depleting actions of the stimulant were fully restored. The latter 
      findings suggest that it is the hypothermic actions of L-NAME, rather than its NO 
      inhibitory properties, that are responsible for the prevention of neurotoxicity. 
      Together with the results of the N(G)-monomethyl-L-arginine and 
      N(G)-nitro-L-arginine experiments, the data suggest that NO plays little or no 
      role in the toxic mechanism of action of METH or MDMA.
FAU - Taraska, T
AU  - Taraska T
AD  - Department of Psychiatry, University of Utah School of Medicine, Veterans 
      Administration Medical Center, Salt Lake City 84148, USA.
FAU - Finnegan, K T
AU  - Finnegan KT
LA  - eng
GR  - DA07239/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Catecholamines)
RN  - 0 (Neurotoxins)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 2149-70-4 (Nitroarginine)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 333DO1RDJY (Serotonin)
RN  - 44RAL3456C (Methamphetamine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - IA7306519N (Isosorbide Dinitrate)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
RN  - VTD58H1Z2X (Dopamine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Analysis of Variance
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Brain/drug effects/*metabolism
MH  - Catecholamines/*metabolism
MH  - Corpus Striatum/metabolism
MH  - Dopamine/metabolism
MH  - Frontal Lobe/metabolism
MH  - Hippocampus/metabolism
MH  - Homovanillic Acid/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Isosorbide Dinitrate/*pharmacology
MH  - Male
MH  - Methamphetamine/*toxicity
MH  - Mice
MH  - Mice, Inbred Strains
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - NG-Nitroarginine Methyl Ester/*pharmacology
MH  - *Neurotoxins
MH  - Nitric Oxide/pharmacology/*physiology
MH  - Nitric Oxide Synthase/antagonists & inhibitors
MH  - Nitroarginine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1997 Feb;280(2):941-7.