PMID- 9026065
OWN - NLM
STAT- MEDLINE
DCOM- 19970218
LR  - 20190522
IS  - 1040-6387 (Print)
IS  - 1040-6387 (Linking)
VI  - 8
IP  - 1
DP  - 1996 Jan
TI  - Comparative pathogenicity of nine US porcine reproductive and respiratory 
      syndrome virus (PRRSV) isolates in a five-week-old cesarean-derived, 
      colostrum-deprived pig model.
PG  - 11-20
AB  - One hundred forty-six 5-week- old cesarean-derived, colostrum-deprived (CDCD) 
      pigs were inoculated intranasally with 1 of 9 US porcine reproductive and 
      respiratory syndrome virus (PRRSV) isolates. Differences were found in severity 
      of clinical respiratory disease, rectal temperatures (P < or = 0.001), gross lung 
      lesions (P < or = 0.001), and microscopic lung lesions (P < or = 0.05). Gross 
      lung lesions were generally most severe 10 days postinoculation and were 
      distributed primarily in the cranial, middle, and accessory lobes and 
      ventromedial portion of the caudal lung lobes. Mean gross lung lesion scores 
      estimating the percentage of lung affected by pneumonia at 10 days 
      postinoculation ranged from 16.7% +/- 2.8% (mean +/- SEM, n = 10) for isolate 
      ISU-51 to 62.4% +/- 5.7% (n = 10) for isolate ISU-28. Microscopic lung lesions 
      were characterized by hyperplastic and hypertrophied type 2 pneumocytes, septal 
      infiltration by mononuclear cells, and accumulation of necrotic alveolar exudate. 
      Lymph node follicular hyperplasia and focal necrosis was seen with all 9 
      isolates. This CDCD pig model was useful for demonstration of significant 
      differences in pathogenicity among US PRRSV isolates. This difference in 
      pathogenicity may help explain the variation of severity of clinical disease 
      observed in field outbreaks of porcine reproductive and respiratory syndrome and 
      should provide for meaningful comparison of PRRSV genotypes.
FAU - Halbur, P G
AU  - Halbur PG
AD  - College of Veterinary Medicine, Iowa State University, Ames 50011, USA.
FAU - Paul, P S
AU  - Paul PS
FAU - Meng, X J
AU  - Meng XJ
FAU - Lum, M A
AU  - Lum MA
FAU - Andrews, J J
AU  - Andrews JJ
FAU - Rathje, J A
AU  - Rathje JA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Vet Diagn Invest
JT  - Journal of veterinary diagnostic investigation : official publication of the 
      American Association of Veterinary Laboratory Diagnosticians, Inc
JID - 9011490
SB  - IM
MH  - Animals
MH  - Arterivirus/isolation & purification/*pathogenicity
MH  - Arterivirus Infections/pathology/physiopathology/*veterinary
MH  - Cesarean Section
MH  - *Colostrum
MH  - Female
MH  - Lung/*pathology/virology
MH  - Lung Diseases/pathology/veterinary/virology
MH  - Pregnancy
MH  - Swine
MH  - *Swine Diseases
MH  - Syndrome
MH  - Virulence
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1177/104063879600800103 [doi]
PST - ppublish
SO  - J Vet Diagn Invest. 1996 Jan;8(1):11-20. doi: 10.1177/104063879600800103.