PMID- 902735
OWN - NLM
STAT- MEDLINE
DCOM- 19771125
LR  - 20191210
IS  - 0014-8318 (Print)
IS  - 0014-8318 (Linking)
VI  - 40
IP  - 4
DP  - 1977 Jul-Aug
TI  - [Effect of serotonin and monoamine oxidase inhibitors on corneal anesthesia 
      produced by celnovocaine and novocaine].
PG  - 393-7
AB  - In experiments on guinea pigs it is shown that a preliminary intraperitoneal 
      administration of monoamine oxidase inhibitors (MAOI) -- transamine (10 mg/kg) or 
      malic acid benzyldihydrazide (50 mg/kg) antagonizes the local anesthetic action 
      of celnovocaine (CC) and novocaine (NC). An analogous effect is also observed 
      following instillation of transamine (a 0.1% solution) and malic acid 
      benzyldihydrazide (a 0.23% solution) into the eye 10 minutes before 
      administration of the anesthetic. Instillation of a 0.1% serotonin creatinine 
      sulphate solution also antagonizes anesthesia produced by CC and NC, while MAOI 
      potentiates the effect of serotonin.
FAU - Kalninia, I E
AU  - Kalninia IE
FAU - Baumanis, E A
AU  - Baumanis EA
FAU - Mikazhans, V D
AU  - Mikazhans VD
FAU - Fateev, V A
AU  - Fateev VA
FAU - Baltkais, Ia Ia
AU  - Baltkais IaIa
LA  - rus
PT  - Journal Article
TT  - Vliianie serotonina i ingibitorov monaaminaksidazy no anesteziiu rogovitsy, 
      vyzyvaemuiu tselnovokainom i novokainom.
PL  - Russia (Federation)
TA  - Farmakol Toksikol
JT  - Farmakologiia i toksikologiia
JID - 16920420R
RN  - 0 (Glycolates)
RN  - 0 (Hydrazines)
RN  - 0 (Malates)
RN  - 0 (Monoamine Oxidase Inhibitors)
RN  - 333DO1RDJY (Serotonin)
RN  - 37341-70-1 (celnovocaine)
RN  - 3E3V44J4Z9 (Tranylcypromine)
RN  - 4Z8Y51M438 (Procaine)
SB  - IM
MH  - *Anesthesia, Local
MH  - Animals
MH  - Cornea/*drug effects
MH  - Glycolates/antagonists & inhibitors
MH  - Guinea Pigs
MH  - Hydrazines/pharmacology
MH  - Malates/pharmacology
MH  - Monoamine Oxidase Inhibitors/*pharmacology
MH  - Procaine/*antagonists & inhibitors
MH  - Serotonin/*pharmacology
MH  - Tranylcypromine/pharmacology
EDAT- 1977/07/01 00:00
MHDA- 1977/07/01 00:01
CRDT- 1977/07/01 00:00
PHST- 1977/07/01 00:00 [pubmed]
PHST- 1977/07/01 00:01 [medline]
PHST- 1977/07/01 00:00 [entrez]
PST - ppublish
SO  - Farmakol Toksikol. 1977 Jul-Aug;40(4):393-7.