PMID- 9027392
OWN - NLM
STAT- MEDLINE
DCOM- 19970416
LR  - 20140325
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 744
IP  - 2
DP  - 1997 Jan 9
TI  - Involvement of dopamine-dependent and -independent mechanisms in the rewarding 
      effects mediated by delta opioid receptor subtypes in mice.
PG  - 327-34
AB  - The rewarding effects of the delta 1 opioid receptor agonist [D-Pen2, 
      Pen5]enkephalin (DPDPE) and the delta 2 opioid receptor agonist 
      [D-Ala2]deltorphin II (DELT) on the activity of mesolimbic and nigrostriatal 
      dopamine (DA) neurons were examined in mice. Both DPDPE (15 nmol, i.c.v.) and 
      DELT (5 nmol, i.c.v.) produced a significant place preference in mice. The DPDPE 
      (15 mol, i.c.v.)-induced place preference was abolished by 
      7-benzylidenenaltrexone (BNTX; 0.5 mg/kg, s.c.), a delta1 opioid receptor 
      antagonist, but not by naltriben (NTB; 0.5 mg/kg, s.c.), a delta 2 opioid 
      receptor antagonist. In contrast, the DELT (5 nmol, i.c.v.)-induced place 
      preference was antagonized by NTB, but not BNTX. I.c.v.. injection of DPDPE, but 
      not DELT, at a dose that produced a significant place preference produced a 
      significant elevation of DA turnover in the mouse limbic forebrain, and this 
      effect of DPDPE was antagonized by BNTX but not by NTB. In addition, i.c.v. 
      injection of DPDPE or DELT not affect DA turnover in the mouse striatum. These 
      results suggest that the rewarding effects produced by the activation of central 
      delta 1, but not delta 2, opioid receptors may be caused through the enhancement 
      of the mesolimbic DA neurotransmission, and confirm our previous hypothesis that 
      the DA-dependent and -independent mechanisms may exist in the rewarding effects 
      produced by the activation of central delta opioid receptor subtypes.
FAU - Suzuki, T
AU  - Suzuki T
AD  - Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan. 
      suzuki@hoshi.ap.jp
FAU - Tsuji, M
AU  - Tsuji M
FAU - Mori, T
AU  - Mori T
FAU - Ikeda, H
AU  - Ikeda H
FAU - Misawa, M
AU  - Misawa M
FAU - Nagase, H
AU  - Nagase H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Analgesics)
RN  - 0 (Enkephalins)
RN  - 0 (Receptors, Opioid, delta)
RN  - 88373-73-3 (Enkephalin, D-Penicillamine (2,5)-)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Analgesics/pharmacology
MH  - Animals
MH  - Dopamine/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Enkephalin, D-Penicillamine (2,5)-
MH  - Enkephalins/pharmacology
MH  - Male
MH  - Mice
MH  - Receptors, Opioid, delta/*drug effects
MH  - *Reward
EDAT- 1997/01/09 00:00
MHDA- 1997/01/09 00:01
CRDT- 1997/01/09 00:00
PHST- 1997/01/09 00:00 [pubmed]
PHST- 1997/01/09 00:01 [medline]
PHST- 1997/01/09 00:00 [entrez]
AID - S0006-8993(96)01119-5 [pii]
AID - 10.1016/S0006-8993(96)01119-5 [doi]
PST - ppublish
SO  - Brain Res. 1997 Jan 9;744(2):327-34. doi: 10.1016/S0006-8993(96)01119-5.