PMID- 9027397
OWN - NLM
STAT- MEDLINE
DCOM- 19970416
LR  - 20140325
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 744
IP  - 2
DP  - 1997 Jan 9
TI  - Serotonergic modulation of 3,4-methylenedioxymethamphetamine (MDMA)-elicited 
      reduction of response rate but not rewarding threshold in accumbal 
      self-stimulation.
PG  - 351-7
AB  - In a fixed interval 5-s rate-frequency function paradigm with rats, 
      3,4-methylenedioxymethamphetamine (MDMA; 0.5, 2 and 4 mg/kg) dose-dependently 
      decreased response rate for nucleus accumbens self-stimulation while both 
      D-amphetamine (0.3 and 1 mg/kg) and cocaine (5 and 15 mg /kg) increased response 
      rates. The highest doses of MDMA caused a cessation of responding in many of the 
      rats tested, but in those rats that continued to respond a significant reduction 
      in frequency threshold for self-stimulation was seen. Cocaine and amphetamine 
      dose-dependently reduced frequency threshold in all rats tested. The non-specific 
      serotonin antagonist, methysergide (5 mg/kg), reversed the inhibitory effects of 
      MDMA on response rates and caused all rats to respond following MDMA (4 mg/kg). 
      Methysergide did not affect MDMA's threshold-lowering properties and when 
      administered alone methysergide had not effect on self-stimulation. These results 
      suggest serotonergic involvement in the performance but not 
      reinforcement-modulating effect of MDMA in the self-stimulation paradigm.
FAU - Lin, H Q
AU  - Lin HQ
AD  - Department of Pharmacology, University of Sydney, Australia.
FAU - Jackson, D M
AU  - Jackson DM
FAU - Atrens, D M
AU  - Atrens DM
FAU - Christie, M J
AU  - Christie MJ
FAU - McGregor, I S
AU  - McGregor IS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Nucleus Accumbens/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - *Reward
MH  - Self Stimulation
MH  - Sensory Thresholds/*drug effects
MH  - Serotonin/*pharmacology
EDAT- 1997/01/09 00:00
MHDA- 1997/01/09 00:01
CRDT- 1997/01/09 00:00
PHST- 1997/01/09 00:00 [pubmed]
PHST- 1997/01/09 00:01 [medline]
PHST- 1997/01/09 00:00 [entrez]
AID - S0006-8993(96)01210-3 [pii]
AID - 10.1016/S0006-8993(96)01210-3 [doi]
PST - ppublish
SO  - Brain Res. 1997 Jan 9;744(2):351-7. doi: 10.1016/S0006-8993(96)01210-3.