PMID- 9027641
OWN - NLM
STAT- MEDLINE
DCOM- 19970529
LR  - 20190920
IS  - 0944-1174 (Print)
IS  - 0944-1174 (Linking)
VI  - 31
IP  - 6
DP  - 1996 Dec
TI  - Quantitative analysis of numerical chromosome aberrations in various 
      morphological types of colorectal carcinomas.
PG  - 793-800
AB  - Quantitative analysis by fluorescence in situ hybridization (FISH) on thin 
      paraffin-embedded tissue sections, using specific probes for chromosomes 11, 17, 
      and 18 was employed in various morphological types of early and advanced 
      colorectal cancer to clarify tumor cytogenetics. The chromosome index (CI) was 
      calculated as a quantitative measure of the chromosome copy number. Compared with 
      the CI of normal epithelium, the CI of chromosome 11 in villous components of 
      adenomas or polypoid early cancers was decreased, while the CI in flat type or 
      advanced colorectal cancers, conversely, was increased (P < 0.05). The CI of 
      chromosome 17 in villous components of adenomas and all cancers was higher than 
      that of normal epithelium (P < 0.05), but the differences were not significant. 
      In protruding advanced cancers, the CI of chromosome 18 was significantly 
      decreased (P < 0.01) compared to the CI of normal epithelium. There was no 
      significant chromosomal heterogeneity between the superficial and the deepest 
      layer in each cancer. In mucosa adjacent to sessile and flat type cancers, the CI 
      of chromosome 17 was significantly higher than the CI in normal epithelium or 
      adenomas (P < 0.05). These results suggest that numerical chromosome aberrations 
      are associated with the histological type of adenoma and the morphological 
      diversity of cancer in the colorectum, and that chromosome 17 abnormality occurs 
      in mucosa adjacent to sessile and flat cancers.
FAU - Nanashima, A
AU  - Nanashima A
AD  - First Department of Surgery, Nagasaki University School of Medicine, Japan.
FAU - Tagawa, Y
AU  - Tagawa Y
FAU - Morinaga, M
AU  - Morinaga M
FAU - Kusano, H
AU  - Kusano H
FAU - Nakagoe, T
AU  - Nakagoe T
FAU - Ayabe, H
AU  - Ayabe H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - J Gastroenterol
JT  - Journal of gastroenterology
JID - 9430794
RN  - 0 (DNA Probes)
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Adenocarcinoma/*genetics/pathology
MH  - Adenoma/*genetics/pathology
MH  - Cell Transformation, Neoplastic/genetics/pathology
MH  - *Chromosome Aberrations/genetics
MH  - *Chromosome Disorders
MH  - *Chromosomes, Human, Pair 11/genetics
MH  - *Chromosomes, Human, Pair 17/genetics
MH  - *Chromosomes, Human, Pair 18/genetics
MH  - Colorectal Neoplasms/*genetics/pathology
MH  - DNA Probes/chemistry
MH  - DNA, Neoplasm/analysis
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Intestinal Mucosa/pathology
MH  - Neoplasm Invasiveness
MH  - Retrospective Studies
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - 10.1007/BF02358604 [doi]
PST - ppublish
SO  - J Gastroenterol. 1996 Dec;31(6):793-800. doi: 10.1007/BF02358604.