PMID- 9028156
OWN - NLM
STAT- MEDLINE
DCOM- 19970304
LR  - 20071115
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 38
IP  - 1
DP  - 1997 Jan
TI  - [Rapid onset of hemolytic anemia after allogeneic bone marrow transplantation 
      from an unrelated ABO major mismatched donor].
PG  - 14-20
AB  - A 46-year-old woman with chronic myelogenous leukemia received allogeneic bone 
      marrow transplantation from an unrelated human leukocyte antigen (HLA) matched 
      (but mixed lymphocyte culture (MLC) positive to graft-versus host disease (GvHD) 
      donor. The blood type of the recipient was A type Rh (+) while the donor blood 
      type was B type Rh (+). The patient received busulfan 8 mg/kg, cyclophosphamide 
      120 mg/kg, and total-body irradiation 10 Gy before bone marrow transplantation. 
      Short-term administration of methotrexate and cyclosporin was given for 
      prophylaxis of GvHD. The mononuclear cells harvested from the donor were 
      concentrated by COBE Spectra before bone marrow transplantation. Although 
      engraftment of transplanted bone marrow in the recipient was confirmed on day 11, 
      the patient suffered from severe anemia on day 10. Since the direct Coombs' test 
      to A type red blood cells was positive, and anti-A antibody titer increased 
      16-fold, we diagnosed her anemia as hemolytic anemia caused by ABO mismatched 
      transplantation. In addition to hemolytic anemia, she had skin symptoms of acute 
      GvHD grade II, microangiopathic hemolytic anemia, and died of multiple organ 
      failure on day 44. This experience indicated that some allogeneic transplant 
      recipients are at risk of severe hemolytic anemia in the early stage after 
      unrelated ABO mismatched donor and that it is necessary to establish proper 
      treatment and prophylaxis.
FAU - Watanabe, H
AU  - Watanabe H
AD  - Department of Internal Medicine (III), Jikei University School of Medicine.
FAU - Asai, O
AU  - Asai O
FAU - Tada, N
AU  - Tada N
FAU - Yano, S
AU  - Yano S
FAU - Katoh, A
AU  - Katoh A
FAU - Katori, M
AU  - Katori M
FAU - Kobayashi, T
AU  - Kobayashi T
FAU - Kuraishi, Y
AU  - Kuraishi Y
FAU - Hoshi, Y
AU  - Hoshi Y
FAU - Itoh, K
AU  - Itoh K
FAU - Aizawa, S
AU  - Aizawa S
LA  - jpn
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
RN  - 0 (ABO Blood-Group System)
SB  - IM
MH  - ABO Blood-Group System/*immunology
MH  - Anemia, Hemolytic/*etiology
MH  - *Blood Group Incompatibility
MH  - Bone Marrow Transplantation/*adverse effects
MH  - Female
MH  - Humans
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*therapy
MH  - Middle Aged
MH  - Tissue Donors
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
PST - ppublish
SO  - Rinsho Ketsueki. 1997 Jan;38(1):14-20.