PMID- 9028699
OWN - NLM
STAT- MEDLINE
DCOM- 19970710
LR  - 20190515
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 20
IP  - 1
DP  - 1997 Jan
TI  - The effect of prepubertal diabetes duration on diabetes. Microvascular 
      complications in early and late adolescence.
PG  - 77-80
AB  - OBJECTIVE: To define the significance of prepubertal diabetes duration in the 
      development of diabetic microvascular complications in adolescents. RESEARCH 
      DESIGN AND METHODS: Study A compares complications in 38 prepubertal (PreP) and 
      140 pubertal (Pub) subjects of the same age (10-14 years) and diabetes duration 
      (3-12 years) to determine if the absence of puberty itself confers a lower risk 
      of complications. Study B examines the importance of prepubertal and pubertal 
      diabetes duration in 193 older adolescents (ages 15-22 years) with prepubertal 
      onset of diabetes. Retinopathy status was assessed using stereoscopic fundus 
      photography of seven fields per eye. Albumin excretion rate (AER) was assessed by 
      three consecutive overnight urine collections, using a polyclonal 
      radioimmunoassay. RESULTS: In study A, there were no significant differences 
      between the PreP and Pub groups for retinopathy (27 vs. 29%, P = 0.8) or 
      differences in elevated AER (17 vs. 31%, P = 0.1). In study B, longer prepubertal 
      diabetes duration improved the prediction for retinopathy over postpubertal 
      duration alone (P < 0.0005). No relationship with duration was found for elevated 
      AER (> 7.5, > 15, and > 30 micrograms/min). CONCLUSIONS: Prepubertal subjects 
      with diabetes did not have less retinopathy or elevated albumin excretion 
      compared with pubertal subjects of the same age. Prepubertal diabetes duration is 
      significantly related to the presence of retinopathy in adolescents.
FAU - Donaghue, K C
AU  - Donaghue KC
AD  - Ray Williams Institute of Paediatric Endocrinology, Diabetes and Metabolism, 
      Royal Alexandra Hospital for Children, Westmead, Australia. 
      kimd@mail.kids.usyd.edu.au
FAU - Fung, A T
AU  - Fung AT
FAU - Hing, S
AU  - Hing S
FAU - Fairchild, J
AU  - Fairchild J
FAU - King, J
AU  - King J
FAU - Chan, A
AU  - Chan A
FAU - Howard, N J
AU  - Howard NJ
FAU - Silink, M
AU  - Silink M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 1/*complications
MH  - Diabetic Retinopathy/diagnosis/*epidemiology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - *Puberty
MH  - Time Factors
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.2337/diacare.20.1.77 [doi]
PST - ppublish
SO  - Diabetes Care. 1997 Jan;20(1):77-80. doi: 10.2337/diacare.20.1.77.