PMID- 9029406
OWN - NLM
STAT- MEDLINE
DCOM- 19970515
LR  - 20181113
IS  - 0300-9564 (Print)
IS  - 0300-9564 (Linking)
VI  - 103
IP  - 12
DP  - 1996
TI  - Effect of ascorbate and cysteine on the 3,4-methylenedioxymethamphetamine-induced 
      depletion of brain serotonin.
PG  - 1397-404
AB  - The extent of long-term depletion of serotonin (5-HT) produced by 
      3,4-methylenedioxymethamphetmaine (MDMA) was assessed in rats treated with the 
      antioxidants sodium ascorbate or L-cysteine. There was a 30-35% reduction in the 
      striatal concentration of 5-HT 7 days following a single injection of MDMA (20 
      mg/kg, s.c.). MDMA had no significant effect on striatal concentrations of 5-HT 
      in rats that had been treated with ascorbate (250 mg/kg, i.p.) or cysteine (500 
      mg/kg, i.p.) 30 min prior to and 5 hrs following the administration of MDMA. 
      Treatment with ascorbate or cysteine did not alter the accumulation of MDMA in 
      brain as determined by in vivo microdialysis. Moreover, neither ascorbate nor 
      cysteine altered the stimulation of dopamine release elicited by MDMA. These data 
      are supportive of the view that MDMA-induced toxicity of 5-HT neurons may be 
      related to the production of free radicals and subsequent oxidative damage.
FAU - Gudelsky, G A
AU  - Gudelsky GA
AD  - Division of Pharmaceutical Sciences, College of Pharmacy, University of 
      Cincinnati Medical Center, OH, USA.
LA  - eng
GR  - DA 07427/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Neurotoxins)
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - K848JZ4886 (Cysteine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - PQ6CK8PD0R (Ascorbic Acid)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Ascorbic Acid/pharmacology
MH  - Brain/*drug effects/metabolism
MH  - Cysteine/pharmacology
MH  - Dopamine/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/antagonists & inhibitors/*toxicity
MH  - Neuroprotective Agents/*pharmacology
MH  - Neurotoxins/antagonists & inhibitors/*toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
MH  - Serotonin Agents/*toxicity
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1007/BF01271253 [pii]
AID - 10.1007/BF01271253 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 1996;103(12):1397-404. doi: 10.1007/BF01271253.