PMID- 9032484
OWN - NLM
STAT- MEDLINE
DCOM- 19970429
LR  - 20190822
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 10
IP  - 1
DP  - 1997 Jan
TI  - Dietary fat and asthma: is there a connection?
PG  - 6-12
AB  - The last two decades have seen an increase in the prevalence of asthma, eczema, 
      and allergic rhinitis in developed countries. This increase has been paralleled 
      by a fall in the consumption of saturated fat and an increase in the amount of 
      polyunsaturated fat in the diet. This is due to a reduction in the consumption of 
      animal fat and an increase in the use of margarine and vegetable oils containing 
      omega-6 polyunsaturated fatty acids (PUFAs), such as linoleic acid. There is also 
      evidence for a decrease in the consumption of oily fish which contain omega-3 
      PUFAs, such as eicosapentaenoic acid. In a number of countries, there are social 
      class and regional differences in the prevalence of allergic disease, which are 
      associated with differences in the consumption of PUFAs. Linoleic acid is a 
      precursor of arachidonic acid, which can be converted to prostaglandin E2 (PGE2), 
      whereas eicosapentaenoic acid inhibits the formation of PGE2. PGE2 acts on 
      T-lymphocytes to reduce the formation of interferon-gamma (IFN-gamma) without 
      affecting the formation of interleukin-4 (IL-4). This may lead to the development 
      of allergic sensitization, since IL-4 promotes the synthesis of immunoglobulin E 
      (IgE), whereas IFN-gamma has the opposite effect. Changes in the diet may explain 
      the increase in the prevalence of asthma, eczema and allergic rhinitis. The 
      effects of diet may be mediated through an increase in the synthesis of 
      prostaglandin E2 which in turn can promote the formation of immunoglobulin E.
FAU - Black, P N
AU  - Black PN
AD  - Dept of Medicine University of Auckland Auckland Hospital, New Zealand.
FAU - Sharpe, S
AU  - Sharpe S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Arachidonic Acids)
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Fatty Acids)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fatty Acids, Omega-6)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Linoleic Acids)
RN  - 0 (Plant Oils)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 8029-82-1 (Margarine)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9KJL21T0QJ (Linoleic Acid)
RN  - AAN7QOV9EA (Eicosapentaenoic Acid)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Animals
MH  - Arachidonic Acids/biosynthesis/metabolism
MH  - Asthma/*etiology
MH  - Developed Countries
MH  - Dietary Fats/*adverse effects
MH  - Dietary Fats, Unsaturated/administration & dosage
MH  - Dinoprostone/antagonists & inhibitors/biosynthesis
MH  - Eczema/etiology
MH  - Eicosapentaenoic Acid/administration & dosage/pharmacology
MH  - Fatty Acids/administration & dosage
MH  - Fatty Acids, Omega-3/administration & dosage
MH  - Fatty Acids, Omega-6
MH  - Fatty Acids, Unsaturated/administration & dosage
MH  - Feeding Behavior
MH  - Fishes
MH  - Humans
MH  - Immunoglobulin E/biosynthesis
MH  - Interferon-gamma/antagonists & inhibitors
MH  - Interleukin-4/biosynthesis
MH  - Linoleic Acid
MH  - Linoleic Acids/administration & dosage
MH  - Margarine
MH  - Plant Oils/administration & dosage
MH  - Prevalence
MH  - Respiratory Hypersensitivity/etiology
MH  - Rhinitis/etiology
MH  - Social Class
MH  - T-Lymphocytes/metabolism
RF  - 72
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1183/09031936.97.10010006 [doi]
PST - ppublish
SO  - Eur Respir J. 1997 Jan;10(1):6-12. doi: 10.1183/09031936.97.10010006.