PMID- 9032791
OWN - NLM
STAT- MEDLINE
DCOM- 19970416
LR  - 20180216
IS  - 0030-3747 (Print)
IS  - 0030-3747 (Linking)
VI  - 28
IP  - 6
DP  - 1996
TI  - Role of catalase in retinal antioxidant defence system: its comparative study 
      among rabbits, guinea pigs, and rats.
PG  - 336-42
AB  - The role of catalase in the retinal antioxidant defence system was examined in 
      rabbits, guinea pigs, and rats with and without prolonged administration of a 
      diet containing 0.4% 3-aminotriazole (3-AT), a catalase inhibitor. When weanling 
      rabbits, guinea pigs, and rats we administered 3-AT for 8, 7, and 10 weeks, 
      respectively, retinal catalase activity was reduced by approximately 50% in all 
      these animals. In the retina of rabbits with 3-AT administration, a decrease in 
      superoxide dismutase (SOD) activity and an increase in lipid peroxide (LPO) 
      concentration occurred. while glutathione peroxidase (GSH-px) activity did not 
      change. In the retina of guinea pigs with 3-AT administration, an increase in LPO 
      concentration occurred, while SOD and GSH-px activities did not change. In the 
      retina of rats with 3-AT administration, a decrease in GSH-px activity and an 
      increase in LPO concentration occurred, while SOD activity did not change. An 
      increase in serum LPO concentration was found in rats with 3-AT administration, 
      while the concentration did not change in rabbits and guinea pigs. These results 
      indicate that catalase plays an important role in the retinal antioxidant defence 
      system, but that the way catalase contributes to the maintenance of the retinal 
      antioxidant defence system is different among these animals. The present results 
      suggest that under the prolonged inhibition of catalase, the retina of rats, but 
      not of rabbits and guinea pigs, may suffer from the influence of systemic 
      oxidative stress.
FAU - Ohta, Y
AU  - Ohta Y
AD  - Department of Biochemistry, School of Medicine, Fujita Health University, 
      Toyoake, Japan.
FAU - Yamasaki, T
AU  - Yamasaki T
FAU - Niwa, T
AU  - Niwa T
FAU - Niimi, K
AU  - Niimi K
FAU - Majima, Y
AU  - Majima Y
FAU - Ishiguro, I
AU  - Ishiguro I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Switzerland
TA  - Ophthalmic Res
JT  - Ophthalmic research
JID - 0267442
RN  - 0 (Antioxidants)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Lipid Peroxides)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - ZF80H5GXUF (Amitrole)
SB  - IM
MH  - Amitrole/administration & dosage
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Catalase/antagonists & inhibitors/*physiology
MH  - Diet
MH  - Enzyme Inhibitors/administration & dosage
MH  - Glutathione Peroxidase/*metabolism
MH  - Guinea Pigs
MH  - Lipid Peroxides/*metabolism
MH  - Male
MH  - Oxidative Stress
MH  - Rabbits
MH  - Rats
MH  - Rats, Wistar
MH  - Retina/*physiology
MH  - Superoxide Dismutase/*metabolism
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1159/000267925 [doi]
PST - ppublish
SO  - Ophthalmic Res. 1996;28(6):336-42. doi: 10.1159/000267925.