PMID- 9038756
OWN - NLM
STAT- MEDLINE
DCOM- 19970311
LR  - 20190501
IS  - 0021-9746 (Print)
IS  - 1472-4146 (Electronic)
IS  - 0021-9746 (Linking)
VI  - 49
IP  - 9
DP  - 1996 Sep
TI  - Immunohistological analysis of tumour growth factor beta 1 expression in normal 
      and inflamed salivary glands.
PG  - 728-32
AB  - AIM: To determine whether transforming growth factor-beta 1 (TGF-beta 1) has a 
      pathogenetic role in disease of the salivary glands. METHODS: An indirect 
      immunohistochemical technique was used to analyse TGF-beta 1 expression in six 
      specimens of normal salivary gland and 23 surgical specimens. RESULTS: TGF-beta 1 
      was strongly expressed in the ductal epithelial cells of normal salivary gland 
      tissues (six of six cases) and in inflammatory conditions (eight of 11 cases). In 
      contrast, TGF-beta 1 was not detectable in ductal epithelial cells expressing 
      HLA-DR around infiltrating CD4+ CD45RO+ activated T cells, in the salivary gland 
      tissue of patients with Sjogren's syndrome. CONCLUSION: Because TGF-beta 1 has an 
      essential role in the mucosal immunity of salivary glands, abnormal expression of 
      this cytokine must be regarded as a candidate in the pathogenesis of Sjogren's 
      syndrome.
FAU - Kizu, Y
AU  - Kizu Y
AD  - Department of Oral Medicine, Tokyo Dental College, Chiba, Japan.
FAU - Sakurai, H
AU  - Sakurai H
FAU - Katagiri, S
AU  - Katagiri S
FAU - Shinozaki, N
AU  - Shinozaki N
FAU - Ono, M
AU  - Ono M
FAU - Tsubota, K
AU  - Tsubota K
FAU - Saito, J
AU  - Saito J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Clin Pathol
JT  - Journal of clinical pathology
JID - 0376601
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Transforming Growth Factor beta)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers
MH  - CD4-Positive T-Lymphocytes/pathology
MH  - Case-Control Studies
MH  - Epithelium/pathology
MH  - Female
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - Leukocyte Common Antigens
MH  - Male
MH  - Middle Aged
MH  - Sialadenitis/*pathology
MH  - Sjogren's Syndrome/complications/*pathology
MH  - Transforming Growth Factor beta/*analysis
PMC - PMC500721
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
PMCR- 1999/09/01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
PHST- 1999/09/01 00:00 [pmc-release]
AID - 10.1136/jcp.49.9.728 [doi]
PST - ppublish
SO  - J Clin Pathol. 1996 Sep;49(9):728-32. doi: 10.1136/jcp.49.9.728.