PMID- 9039009
OWN - NLM
STAT- MEDLINE
DCOM- 19970331
LR  - 20180618
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 272
IP  - 1 Pt 2
DP  - 1997 Jan
TI  - A source of adenosine involved in cardiovascular responses to defense area 
      stimulation.
PG  - R195-200
AB  - We have investigated the source of central adenosine important in modulating the 
      cardiovascular response to hypothalamic defense area (HDA) stimulation in 
      alpha-chloralose-anesthetized rats. Microinjections of an ecto-5'-nucleotidase 
      inhibitor, alpha,beta-methylene ADP (alpha,beta-meADP), were made into caudal 
      nucleus of the solitary tract (cNTS) and rostral ventrolateral medulla (RVLM), 
      and its effects on HDA-evoked responses were observed. Stimulation of HDA evoked 
      an increase in arterial pressure and a secondary rise in arterial pressure after 
      stimulation ceased. There was also an increase in heart rate and hindlimb blood 
      flow. alpha,beta-meADP had no effect on resting levels of arterial pressure, 
      heart rate, and hindlimb blood flow when injected into the cNTS or RVLM. 
      alpha,beta-meADP also had no effect on the HDA-evoked tachycardia and increase in 
      muscle blood flow. However, alpha,beta-meADP reduced the primary increase in 
      arterial pressure evoked by HDA stimulation when microinjected into the cNTS. In 
      contrast, alpha,beta-meADP reduced the secondary increase in arterial pressure 
      when microinjected into the RVLM. From these results, we suggest that at least 
      part of the adenosine released centrally during HDA stimulation is derived 
      extracellularly from ATP metabolism.
FAU - St Lambert, J H
AU  - St Lambert JH
AD  - Department of Physiology, Royal Free Hospital School of Medicine, London, United 
      Kingdom.
FAU - Thomas, T
AU  - Thomas T
FAU - Burnstock, G
AU  - Burnstock G
FAU - Spyer, K M
AU  - Spyer KM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Enzyme Inhibitors)
RN  - 0T2A5439OE (alpha,beta-methyleneadenosine 5'-diphosphate)
RN  - 61D2G4IYVH (Adenosine Diphosphate)
RN  - EC 3.1.3.5 (5'-Nucleotidase)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - 5'-Nucleotidase/antagonists & inhibitors
MH  - Adenosine/*physiology
MH  - Adenosine Diphosphate/analogs & derivatives/pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - *Cardiovascular Physiological Phenomena
MH  - Cardiovascular System/drug effects
MH  - *Defense Mechanisms
MH  - Electric Stimulation
MH  - Enzyme Inhibitors/pharmacology
MH  - Femoral Artery/drug effects/physiology
MH  - Heart Rate/drug effects
MH  - Male
MH  - Medulla Oblongata/physiology
MH  - Microinjections
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Regional Blood Flow/drug effects
MH  - Solitary Nucleus/physiology
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1152/ajpregu.1997.272.1.R195 [doi]
PST - ppublish
SO  - Am J Physiol. 1997 Jan;272(1 Pt 2):R195-200. doi: 
      10.1152/ajpregu.1997.272.1.R195.