PMID- 9039442
OWN - NLM
STAT- MEDLINE
DCOM- 19970311
LR  - 20191101
IS  - 0962-8479 (Print)
IS  - 0962-8479 (Linking)
VI  - 77
IP  - 6
DP  - 1996 Dec
TI  - Anti-IgG autoantibodies and possible immune regulatory mechanisms in patients 
      with pulmonary tuberculosis.
PG  - 502-9
AB  - SETTING: Anti-Ig antibodies are known to have important clinical and biological 
      implications. OBJECTIVES: To determine naturally occurring anti-F(ab')2 gamma and 
      anti-Fc gamma antibodies in patients with pulmonary tuberculosis (PTB) in 
      relation to various clinical manifestations and human leukocyte antigen (HLA). 
      DESIGN: Antibodies to F(ab')2 and Fc portions of IgG were detected in the sera of 
      normal healthy individuals (n = 41), patients with pulmonary tuberculosis (n = 
      50) and their household family contacts (n = 20) using an enzyme immuno assay 
      (EIA) system. RESULTS: As compared to controls (0.110 +/- 0.01 optical density 
      [OD]), the levels of anti-F(ab')2 gamma were significantly increased in PTB 
      patients (0.998 +/- 0.08 OD, P < 0.0001) and in their contacts (0.486 +/- 0.04 
      OD, P < 0.001) suggesting that the occurrence of these autoantibodies is related 
      to infection/exposure to Mycobacterium tuberculosis. Anti-F(ab')2 gamma 
      antibodies were significantly increased in both sputum positive and negative 
      patients (P < 0.0001) and no deviation was observed between these two groups. The 
      levels of these antibodies were positively correlated with disease severity 
      assessed by chest X-ray. The drug failure patients had higher activity of 
      anti-F(ab')2 gamma than drug responders and no impact of anti-tuberculosis 
      chemotherapy was observed. A statistically significant increase of anti-F(ab')2 
      gamma levels (1.25 +/- 0.21 OD) was observed in HLA-DR2 positive patients as 
      compared to the DR2 negative groups (1.02 +/- 0.09 OD), P < 0.01. No deviation 
      was observed in the levels of anti-Fc gamma levels between controls and any group 
      of PTB patients. CONCLUSION: The present data suggests that the elevated levels 
      of anti-F(ab')2 gamma antibodies in PTB patients represent an anti-idiotypic 
      antibody response to anti-M. tuberculosis antibody caused by an immune imbalance 
      following M. tuberculosis infection.
FAU - Rajalingam, R
AU  - Rajalingam R
AD  - Department of Histocompatibility and Immunogenetics, All India Institute of 
      Medical Sciences, New Delhi, India.
FAU - Mehra, N K
AU  - Mehra NK
FAU - Chopra, G S
AU  - Chopra GS
FAU - Puri, M M
AU  - Puri MM
FAU - Jain, R C
AU  - Jain RC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Scotland
TA  - Tuber Lung Dis
JT  - Tubercle and lung disease : the official journal of the International Union 
      against Tuberculosis and Lung Disease
JID - 9212467
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Antitubercular Agents)
RN  - 0 (HLA-DR2 Antigen)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Antibodies, Anti-Idiotypic/*blood
MH  - Antitubercular Agents/therapeutic use
MH  - Bacillus/isolation & purification
MH  - Female
MH  - HLA-DR2 Antigen/blood
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - *Immunoglobulin G
MH  - Male
MH  - Radiography
MH  - Sputum/microbiology
MH  - Tuberculosis, Pulmonary/diagnostic imaging/drug therapy/*immunology
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - S0962-8479(96)90047-7 [pii]
AID - 10.1016/s0962-8479(96)90047-7 [doi]
PST - ppublish
SO  - Tuber Lung Dis. 1996 Dec;77(6):502-9. doi: 10.1016/s0962-8479(96)90047-7.