PMID- 9039714
OWN - NLM
STAT- MEDLINE
DCOM- 19970312
LR  - 20131121
IS  - 0007-0947 (Print)
IS  - 0007-0947 (Linking)
VI  - 50
IP  - 8
DP  - 1996 Dec
TI  - Allergic reactions to local glyceryl trinitrate administration.
PG  - 437-9
AB  - To assess the exact cause and extent of transdermal glyceryl trinitrate 
      (GTN)-induced allergic reactions, a study of continuous and intermittent use of 
      GTN patches was conducted in 320 patients with New York Heart Association (NYHA) 
      class II and III angina pectoris. Three commercially available GTN patch systems 
      were used. Twenty-one patients (6.5%) developed cutaneous reactions. In 17 
      patients (5.3%), the reactions were confined to the area of application and were 
      characterised as irritant reactions. Four patients (1.2%) developed both 
      localised and remote from the area of application lesions and one patient 
      developed a generalised anaphylactic reaction. The rate of discontinuation of 
      therapy was 3.4%. The irritant skin reactions were mainly due to contaminants and 
      additives. Changing to a different transdermal system reduced the incidence of 
      local reactions--a particularly desirable effect in patients who respond well to 
      GTN therapy.
FAU - Kounis, N G
AU  - Kounis NG
AD  - Department of Medicine, Agios Andreas General Hospital, Patras, Greece.
FAU - Zavras, G M
AU  - Zavras GM
FAU - Papadaki, P J
AU  - Papadaki PJ
FAU - Soufras, G D
AU  - Soufras GD
FAU - Poulos, E A
AU  - Poulos EA
FAU - Goudevenos, J
AU  - Goudevenos J
FAU - Alangoussis, A
AU  - Alangoussis A
FAU - Antonakopoulos, K
AU  - Antonakopoulos K
FAU - Frangides, C
AU  - Frangides C
FAU - Peristeropoulou, S A
AU  - Peristeropoulou SA
FAU - Koutsojannis, C
AU  - Koutsojannis C
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - England
TA  - Br J Clin Pract
JT  - The British journal of clinical practice
JID - 0372546
RN  - 0 (Adhesives)
RN  - 0 (Silicones)
RN  - G59M7S0WS3 (Nitroglycerin)
RN  - PDC6A3C0OX (Glycerol)
SB  - IM
MH  - Adhesives/adverse effects
MH  - Administration, Cutaneous
MH  - Aged
MH  - Angina Pectoris/drug therapy
MH  - Dermatitis, Contact/etiology
MH  - Drug Administration Schedule
MH  - Drug Eruptions/*etiology
MH  - Female
MH  - Glycerol/adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/drug therapy
MH  - Nitroglycerin/administration & dosage/*adverse effects
MH  - Patch Tests
MH  - Silicones/adverse effects
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
PST - ppublish
SO  - Br J Clin Pract. 1996 Dec;50(8):437-9.