PMID- 9040055
OWN - NLM
STAT- MEDLINE
DCOM- 19970527
LR  - 20061115
IS  - 0022-2828 (Print)
IS  - 0022-2828 (Linking)
VI  - 29
IP  - 1
DP  - 1997 Jan
TI  - Plasma levels of the monocyte chemotactic and activating factor/monocyte 
      chemoattractant protein-1 are elevated in patients with acute myocardial 
      infarction.
PG  - 419-23
AB  - Cardiac inflammatory responses appear to play a pivotal role in scar formation 
      after acute myocardial infarction. Monocyte chemotactic and activating factor 
      (MCAF) monocyte chemoattractant protein-1 (MCP-1) is a cytokine with chemotactic 
      activity for mononuclear phagocytes, but also for NK cells, T cells, mast cells, 
      and basophils. To investigate the possible involvement of MCAF/MCP-1 in the 
      pathogenesis, its course was studied in patients with acute myocardial 
      infarction. Twenty-three consecutive patients with acute myocardial infarction 
      and 18 patients with angina pectoris were studied. Cytokines were measured by 
      enzyme-linked immunosorbent assay. Plasma levels of interleukin IL-1alpha, 
      IL-1beta, and IL-2 were below the detection limit of our method. IL-6 and 
      interferon-gamma were detected in 17.4%, and tumor necrosis factor-alpha in 13.0% 
      of patients with acute myocardial infarction, but the frequency was not 
      statistically significantly different from that in angina pectoris. The plasma 
      level of MCAF/MCP-1 in myocardial infarction tended to increase at 3 h after the 
      onset of chest pain (133 +/- 19 pg/ml, P= 0.06) and was significantly elevated at 
      9 h (143 +/- 20 pg/ml) when compared with that in angina pectoris (87 +/- 6 
      pg/ml, P<0.05). The MCAF/MCP-1 level remained increased during the 24-hours 
      observation period (P<0.01), and maximum level (168 +/- 13 pg/ml) was seen at 24 
      hour. The level of MCAF/ MCP-1 correlated significantly with the plasma level of 
      another chemokine, IL-8, at 12 h after the onset of chest pain (r=0.51, P<0.05), 
      suggesting that common stimuli mediate the release of both cytokines in 
      myocardial infarction. The identification of MCAF/MCP-1 as an inflammatory 
      mediator in acute myocardial infarction suggests that mononuclear phagocytes may 
      play an important role in the early stage of the disease.
FAU - Matsumori, A
AU  - Matsumori A
AD  - Department of Cardiovascular Medicine, Kyoto University, Sakyo-ku, Japan.
FAU - Furukawa, Y
AU  - Furukawa Y
FAU - Hashimoto, T
AU  - Hashimoto T
FAU - Yoshida, A
AU  - Yoshida A
FAU - Ono, K
AU  - Ono K
FAU - Shioi, T
AU  - Shioi T
FAU - Okada, M
AU  - Okada M
FAU - Iwasaki, A
AU  - Iwasaki A
FAU - Nishio, R
AU  - Nishio R
FAU - Matsushima, K
AU  - Matsushima K
FAU - Sasayama, S
AU  - Sasayama S
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Mol Cell Cardiol
JT  - Journal of molecular and cellular cardiology
JID - 0262322
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angina Pectoris/blood
MH  - Chemokine CCL2/*blood
MH  - Cytokines/blood
MH  - Female
MH  - Humans
MH  - Interleukin-8/*blood
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - S0022-2828(96)90285-0 [pii]
AID - 10.1006/jmcc.1996.0285 [doi]
PST - ppublish
SO  - J Mol Cell Cardiol. 1997 Jan;29(1):419-23. doi: 10.1006/jmcc.1996.0285.