PMID- 9040713
OWN - NLM
STAT- MEDLINE
DCOM- 19970326
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 48
IP  - 2
DP  - 1997 Feb
TI  - HTLV-associated myelopathy in a cohort of HTLV-I and HTLV-II-infected blood 
      donors. The REDS investigators.
PG  - 315-20
AB  - OBJECTIVE: HTLV-I-associated myelopathy (HAM) is a slowly progressive spastic 
      paraparesis caused by infection with human T-lymphotropic virus type I (HTLV-I). 
      The prevalence of HAM among those infected with HTLV-I is poorly defined, and the 
      association of a similar myelopathy with HTLV-II infection has not been 
      confirmed. DESIGN: Cross-sectional examination of HTLV-I, HTLV-II, and control 
      subjects from the baseline visit of a cohort study. SETTING/ SUBJECTS: Persons 
      testing HTLV seropositive at the time of blood donation at five U.S. blood 
      centers, their seropositive sex partners, and a matched control group of HTLV 
      seronegative blood donors. MEASUREMENTS: HTLV-I and HTLV-II were differentiated 
      by serology and/or polymerase chain reaction. All subjects received systematic 
      neurologic screening examinations. RESULTS: A diagnosis of myelopathy was 
      confirmed in four of 166 HTLV-I subjects (2.4%, 95% confidence interval 0.7%, 
      6.1%) and in one of 404 HTLV-II subjects (0.25%, 95% confidence interval 0.0%, 
      0.6%). None of the 798 controls had a similar myelopathy, although one had 
      longstanding typical multiple sclerosis. CONCLUSIONS: Our data also suggest that 
      HAM occurs more frequently among HTLV-I-infected subjects than reported by 
      previous studies. The HTLV-II infected myelopathy patient identified in this 
      cohort, together with three other case reports in the literature, implies a 
      pathogenic role for this human retrovirus. The diagnosis of HTLV-associated 
      myelopathy should be considered in cases of spastic paraparesis or neurogenic 
      bladder when risk factors for HTLV-I or HTLV-II infection are present.
FAU - Murphy, E L
AU  - Murphy EL
AD  - Department of Laboratory Medicine, University of California, San Francisco 
      94143-0884, USA.
FAU - Fridey, J
AU  - Fridey J
FAU - Smith, J W
AU  - Smith JW
FAU - Engstrom, J
AU  - Engstrom J
FAU - Sacher, R A
AU  - Sacher RA
FAU - Miller, K
AU  - Miller K
FAU - Gibble, J
AU  - Gibble J
FAU - Stevens, J
AU  - Stevens J
FAU - Thomson, R
AU  - Thomson R
FAU - Hansma, D
AU  - Hansma D
FAU - Kaplan, J
AU  - Kaplan J
FAU - Khabbaz, R
AU  - Khabbaz R
FAU - Nemo, G
AU  - Nemo G
LA  - eng
GR  - N01-HB-97077/HB/NHLBI NIH HHS/United States
GR  - N01-HB-97078/HB/NHLBI NIH HHS/United States
GR  - N01-HB-97079/HB/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
MH  - AIDS Serodiagnosis
MH  - Adult
MH  - Blood Donors
MH  - Cohort Studies
MH  - Epidemiologic Methods
MH  - Female
MH  - HTLV-I Infections/*complications/*epidemiology
MH  - HTLV-II Infections/*complications/*epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neurologic Examination
MH  - Paraparesis, Tropical Spastic/diagnosis/*epidemiology
MH  - Risk Factors
MH  - Sexual Partners
MH  - Urinary Incontinence/complications
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.1212/wnl.48.2.315 [doi]
PST - ppublish
SO  - Neurology. 1997 Feb;48(2):315-20. doi: 10.1212/wnl.48.2.315.