PMID- 9040788
OWN - NLM
STAT- MEDLINE
DCOM- 19970313
LR  - 20180214
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 75
IP  - 2-3
DP  - 1996
TI  - Mapping of 29 YAC clones and identification of 3 YACs spanning the translocation 
      t(3;8)(p14.2;q24.1) breakpoint at 8q24.1 in hereditary renal cell carcinoma.
PG  - 180-5
AB  - The constitutional balanced translocation (3;8)(p14.2:q24.1) has been described 
      in a family in which a arge number of individuals developed renal cell carcinoma 
      RCC) at an early age. The translocation event in which genes from the 3p14.2 and 
      the 8q24.1 sites are brought in close proximity is considered a critical, initial 
      step for the development and progression of RCC. Even though the 3p14.2 
      breakpoint region has been cloned, a gene has not yet been identified, which may 
      be responsible for either the initiation or progression of hereditary RCC. As a 
      crucial step toward cloning the 3;8 breakpoint at the 8q24.1 site, we have mapped 
      a series of YACs which surround this region by fluorescence in situ hybridization 
      (FISH). Three YACs have been identified that span the 8q24.1 breakpoint region. 
      One of these YACs is approximately 180 kb in length, and has been used to 
      initiate construction of a high resolution cosmid contig. Several cosmids have 
      been isolated which have been positioned in relation to the 8q24.1 breakpoint 
      region. In addition, we have positioned 26 other YACs in relation to the 3;8 
      translocation breakpoint. These results provide a basis for the isolation of 
      genes surrounding 3;8 RCC translocation breakpoint region at 8q24.1.
FAU - Shi, G
AU  - Shi G
AD  - Department of Pathology, Albert Einstein College of Medicine, Bronx NY, USA.
FAU - Cannizzaro, L A
AU  - Cannizzaro LA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Carcinoma, Renal Cell/*genetics
MH  - Cell Line, Transformed
MH  - Chromosome Mapping
MH  - *Chromosomes, Artificial, Yeast
MH  - Chromosomes, Human, Pair 3/*genetics
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Cosmids
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/*genetics
MH  - *Translocation, Genetic
MH  - Tumor Cells, Cultured
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1159/000134473 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1996;75(2-3):180-5. doi: 10.1159/000134473.