PMID- 9042631
OWN - NLM
STAT- MEDLINE
DCOM- 19970430
LR  - 20190822
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 10
IP  - 2
DP  - 1997 Feb
TI  - Factors relating to the severity of symptoms at 5 yrs in children with severe 
      wheeze in the first 2 yrs of life.
PG  - 346-53
AB  - Wheezing in early childhood covers a wide spectrum of morbidity. Since little is 
      known about the factors determining either the pattern or the severity of this 
      range of symptoms, 51 children, admitted to hospital with acute wheeze in the 
      first 2 yrs of life, were monitored prospectively between the ages of 4.5-5.5 
      yrs. Our hypothesis was that the predictors of severe episodes and of interval 
      symptoms in 5 year olds would differ. Symptom diaries were kept, from which the 
      symptom pattern and severity was assessed. The frequency and severity of acute 
      episodes were analysed separately from day-to-day (interval) symptoms. A 
      physiological assessment was made at 5 yrs. During the 12 month study period, 11 
      children were symptom-free, 15 were reported to wheeze only in response to viral 
      infections, and 25 wheezed from multiple triggers. Bronchial responsiveness was 
      significantly increased in those with a family history of asthma but was 
      unrelated to any index of atopy. In a multiple logistic regression analysis, a 
      family history of asthma and a personal history of allergy (but not results of 
      skin-prick testing or serum immunoglobulin E (IgE) significantly predicted both 
      attack severity and interval symptoms. An additive effect of two factors (atopy 
      plus a family history of asthma or bronchial responsiveness) on symptom severity 
      was suggested, without any evidence of an interaction. It is concluded that in 
      this population of 5 year olds, with an early history of severe wheezing, 
      familial bronchial responsiveness and atopy of operated independently to 
      determine both interval symptoms and attack severity.
FAU - Wilson, N M
AU  - Wilson NM
AD  - Dept of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, 
      Hammersmith, London, UK.
FAU - Dore, C J
AU  - Dore CJ
FAU - Silverman, M
AU  - Silverman M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0W5ETF9M2K (Methacholine Chloride)
SB  - IM
MH  - Acute Disease
MH  - Airway Resistance
MH  - Asthma/genetics
MH  - Bronchial Provocation Tests
MH  - Child, Preschool
MH  - Female
MH  - Follow-Up Studies
MH  - Hospitalization
MH  - Humans
MH  - Hypersensitivity/complications/diagnosis
MH  - Male
MH  - Methacholine Chloride
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Respiratory Sounds/*etiology
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.1183/09031936.97.10020346 [doi]
PST - ppublish
SO  - Eur Respir J. 1997 Feb;10(2):346-53. doi: 10.1183/09031936.97.10020346.