PMID- 9043842
OWN - NLM
STAT- MEDLINE
DCOM- 19970505
LR  - 20190512
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 18
IP  - 2
DP  - 1997 Feb
TI  - Prognostic value of plasma endothelin-1 in patients with chronic heart failure.
PG  - 254-8
AB  - AIMS: Endothelin-1 is a potent vasoconstrictive and multifunctional peptide. 
      Elevated concentrations have been reported in congestive heart failure. We 
      hypothesized that the level of endothelin-1 in plasma is a prognostic marker in 
      congestive heart failure. METHODS AND RESULTS: Plasma levels of endothelin-1 were 
      measured by radioimmunoassay in 120 congestive heart failure patients with 
      ischaemic or non-ischaemic cardiomyopathy (mean ejection fraction 28 +/- 11%, in 
      New York Heart Association (NYHA) functional class I:21, class II 35, class III: 
      61, class IV: 3). During a median follow-up of 361 +/- 338 days, 14 cardiac 
      deaths occurred. In the univariate Cox model, endothelin-1 was the most powerful 
      prognostic marker among the variables tested (P = 0.0001). A multivariate model, 
      including plasma atrial natriuretic peptide and noradrenaline, NYHA class, age, 
      and echocardiographic left ventricular end-diastolic diameter index was highly 
      predictive of mortality (P = 0.00008), but only endothelin-1 remained 
      significantly associated with outcome (P = 0.02). Patients with plasma 
      endothelin-1 > or = 5 pg. ml-1 had a higher mortality rate than those with 
      endothelin-1 < 5 pg. ml-1 (21% vs 4%, P = 0.001). CONCLUSION: Our results suggest 
      that elevated endothelin-1 plasma levels are associated with a poor prognosis and 
      routine plasma endothelin-1 determination provides important prognostic 
      information in mild to moderate heart failure.
FAU - Pousset, F
AU  - Pousset F
AD  - Department of Cardiology, Pitie-Salpetriere Hospital, Paris, France.
FAU - Isnard, R
AU  - Isnard R
FAU - Lechat, P
AU  - Lechat P
FAU - Kalotka, H
AU  - Kalotka H
FAU - Carayon, A
AU  - Carayon A
FAU - Maistre, G
AU  - Maistre G
FAU - Escolano, S
AU  - Escolano S
FAU - Thomas, D
AU  - Thomas D
FAU - Komajda, M
AU  - Komajda M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
RN  - 0 (Biomarkers)
RN  - 0 (Endothelin-1)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Atrial Natriuretic Factor/blood
MH  - Biomarkers/blood
MH  - Chronic Disease
MH  - Death
MH  - Echocardiography
MH  - Endothelin-1/*blood
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*blood/diagnostic imaging/mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Norepinephrine/blood
MH  - Prognosis
MH  - Radioimmunoassay
MH  - Survival Rate
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.eurheartj.a015228 [doi]
PST - ppublish
SO  - Eur Heart J. 1997 Feb;18(2):254-8. doi: 10.1093/oxfordjournals.eurheartj.a015228.