PMID- 9043952
OWN - NLM
STAT- MEDLINE
DCOM- 19970501
LR  - 20190512
IS  - 0953-8178 (Print)
IS  - 0953-8178 (Linking)
VI  - 9
IP  - 1
DP  - 1997 Jan
TI  - Active catabolism of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase in 
      vivo is a necessary requirement for natural resistance to infection with Listeria 
      monocytogenes.
PG  - 105-15
AB  - The results from the present study demonstrate that the innate defense mechanisms 
      which control the progressive growth of Listeria monocytogenes in normal animals 
      in vivo are dependent upon the active catabolism of endogenous glucocorticoids by 
      the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD). When 11 beta-HSD 
      activity was pharmacologically inhibited in vivo, host susceptibility to 
      progressive bacterial disease was markedly increased. Depressed natural 
      resistance following 11 beta-HSD inhibition correlated with changes in the 
      patterns of inducible cytokines by macrophages and T cells. Similar changes were 
      observed when normal adult animals were treated with low doses of dexamethasone 
      prior to experimental infection with Listeria.
FAU - Hennebold, J D
AU  - Hennebold JD
AD  - Department of Pathology, University of Utah School of Medicine, Salt Lake City 
      84132, USA.
FAU - Mu, H H
AU  - Mu HH
FAU - Poynter, M E
AU  - Poynter ME
FAU - Chen, X P
AU  - Chen XP
FAU - Daynes, R A
AU  - Daynes RA
LA  - eng
GR  - AG11475/AG/NIA NIH HHS/United States
GR  - CA25917/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
RN  - 0 (Cytokines)
RN  - 0 (Glucocorticoids)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenases)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenases
MH  - Animals
MH  - Cytokines/biosynthesis
MH  - Disease Susceptibility
MH  - Female
MH  - Glucocorticoids/*metabolism
MH  - Hydroxysteroid Dehydrogenases/antagonists & inhibitors/*physiology
MH  - Immunity, Innate/drug effects
MH  - Listeriosis/enzymology/*immunology/metabolism
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1093/intimm/9.1.105 [doi]
PST - ppublish
SO  - Int Immunol. 1997 Jan;9(1):105-15. doi: 10.1093/intimm/9.1.105.