PMID- 9044419
OWN - NLM
STAT- MEDLINE
DCOM- 19970709
LR  - 20190726
IS  - 0031-9155 (Print)
IS  - 0031-9155 (Linking)
VI  - 42
IP  - 2
DP  - 1997 Feb
TI  - Single-and dual-energy CT with monochromatic synchrotron x-rays.
PG  - 371-87
AB  - We explored the potential for clinical research of computed tomography (CT) with 
      monochromatic x-rays using the preclinical multiple energy computed tomography 
      (MECT) system at the National Synchrotron Light Source. MECT has a fixed, 
      horizontal fan beam with a subject apparatus rotating about a vertical axis; it 
      will be used for imaging the human head and neck. Two CdWO4-photodiode array 
      detectors with different spatial resolutions were used. A 10.5 cm diameter 
      acrylic phantom was imaged with MECT at 43 keV and with a conventional CT (CCT) 
      at 80 kVp: spatial resolution approximately equal to 6.5 line pairs (lp)/cm for 
      both; slice height, 2.6 mm for MECT against 3.0 mm for CCT; surface dose, 3.1 cGy 
      for MECT against 2.0 cGy for CCT. The resultant image noise was 1.5 HU for MECT 
      against 3 HU for CCT. Computer simulations of the same images with more precisely 
      matched spatial resolution, slice height and dose indicated an image-noise ratio 
      of 1.4:1.0 for CCT against MECT. A 13.5 cm diameter acrylic phantom imaged with 
      MECT at approximately 0.1 keV above the iodine K edge and with CCT showed, for a 
      240 micrograms I ml-1 solution, an image contrast of 26 HU for MECT and 13 and 9 
      HU for the 80 and 100 kVp CCT, respectively. The corresponding numbers from 
      computer simulation of the same images were 26, 12, and 9 HU, respectively. 
      MECT's potential for use in clinical research is discussed.
FAU - Dilmanian, F A
AU  - Dilmanian FA
AD  - Brookhaven National Laboratory, Upton, NY 11973-5000, USA.
FAU - Wu, X Y
AU  - Wu XY
FAU - Parsons, E C
AU  - Parsons EC
FAU - Ren, B
AU  - Ren B
FAU - Kress, J
AU  - Kress J
FAU - Button, T M
AU  - Button TM
FAU - Chapman, L D
AU  - Chapman LD
FAU - Coderre, J A
AU  - Coderre JA
FAU - Giron, F
AU  - Giron F
FAU - Greenberg, D
AU  - Greenberg D
FAU - Krus, D J
AU  - Krus DJ
FAU - Liang, Z
AU  - Liang Z
FAU - Marcovici, S
AU  - Marcovici S
FAU - Petersen, M J
AU  - Petersen MJ
FAU - Roque, C T
AU  - Roque CT
FAU - Shleifer, M
AU  - Shleifer M
FAU - Slatkin, D N
AU  - Slatkin DN
FAU - Thomlinson, W C
AU  - Thomlinson WC
FAU - Yamamoto, K
AU  - Yamamoto K
FAU - Zhong, Z
AU  - Zhong Z
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Phys Med Biol
JT  - Physics in medicine and biology
JID - 0401220
RN  - 0 (Acrylates)
RN  - 9679TC07X4 (Iodine)
SB  - IM
MH  - Acrylates
MH  - Animals
MH  - Computer Simulation
MH  - Equipment Design
MH  - Head
MH  - Humans
MH  - Iodine
MH  - Neck
MH  - *Phantoms, Imaging
MH  - Rabbits
MH  - Synchrotrons
MH  - Tomography, X-Ray Computed/*instrumentation
MH  - X-Rays
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.1088/0031-9155/42/2/009 [doi]
PST - ppublish
SO  - Phys Med Biol. 1997 Feb;42(2):371-87. doi: 10.1088/0031-9155/42/2/009.