PMID- 9046948 OWN - NLM STAT- MEDLINE DCOM- 19970519 LR - 20071115 IS - 0066-4219 (Print) IS - 0066-4219 (Linking) VI - 48 DP - 1997 TI - Use of intravenous immunoglobulin to prevent or treat infections in persons with immune deficiency. PG - 93-102 AB - Intravenous immunoglobulin (IVIG) concentrates were originally developed as replacement therapy for individuals with primary deficiencies of the immune system. However, in various well-designed, controlled clinical trials, the ability of IVIG to prevent and possibly treat infections in patients with secondary immune deficiencies has also been considered. In this review, we briefly consider these different applications and suggest whether the data are sufficient to employ IVIG in these clinical settings. FAU - Lee, M L AU - Lee ML AD - International Quantitative Consultants, Inc., Glendale, California 91203, USA. FAU - Gale, R P AU - Gale RP FAU - Yap, P L AU - Yap PL LA - eng PT - Journal Article PT - Review PL - United States TA - Annu Rev Med JT - Annual review of medicine JID - 2985151R SB - IM MH - Acquired Immunodeficiency Syndrome/immunology/therapy MH - Clinical Trials as Topic MH - Humans MH - Immunization, Passive/*methods MH - Immunologic Deficiency Syndromes/immunology/*therapy MH - Infusions, Intravenous MH - Opportunistic Infections/immunology/*therapy MH - Treatment Outcome RF - 112 EDAT- 1997/01/01 00:00 MHDA- 1997/01/01 00:01 CRDT- 1997/01/01 00:00 PHST- 1997/01/01 00:00 [pubmed] PHST- 1997/01/01 00:01 [medline] PHST- 1997/01/01 00:00 [entrez] AID - 10.1146/annurev.med.48.1.93 [doi] PST - ppublish SO - Annu Rev Med. 1997;48:93-102. doi: 10.1146/annurev.med.48.1.93.