PMID- 9051167
OWN - NLM
STAT- MEDLINE
DCOM- 19970605
LR  - 20231213
IS  - 0360-1293 (Print)
IS  - 0360-1293 (Linking)
VI  - 21
IP  - 3-4
DP  - 1996 Jul-Dec
TI  - Antagonistic action of orphanin FQ on acupuncture analgesia in rat brain.
PG  - 199-205
AB  - The influence of orphanin FQ (OFQ) (a newly discovered 17-amino acid peptide) on 
      acupuncture analgesia (AA) was assessed in rat tail-flick model. 
      Intracerebroventricular (i.c.v.) injection of OFQ (1 microgram) elicited a 
      significant decrement of pain threshold which was abolished by the repeated 
      pretreatment with antisense oligonucleotide (ASO) to OFQ receptor. 
      Electroacupuncture (EA) induced an obvious analgesic effect; when OFQ was used 
      combined with EA, it showed a dose-dependent effect on antagonizing the EA 
      analgesia. When rat was repeatedly i.c.v. injected with ASO to block the 
      synthesis of OFQ receptor, the EA analgesia was enhanced markedly. In this 
      instance, the OFQ did not show antagonistic effect on EA analgesia any more. The 
      results suggest that the OFQ play its antagonistic role on EA analgesia via 
      activating OFQ receptor.
FAU - Zhu, C B
AU  - Zhu CB
AD  - National Key Laboratory of Medical Neurobiology, Shanghai Medical University, 
      China.
FAU - Xu, S F
AU  - Xu SF
FAU - Cao, X D
AU  - Cao XD
FAU - Wu, G C
AU  - Wu GC
FAU - Zhang, X L
AU  - Zhang XL
FAU - Li, M Y
AU  - Li MY
FAU - Cui, D F
AU  - Cui DF
FAU - Chi, C W
AU  - Chi CW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acupunct Electrother Res
JT  - Acupuncture & electro-therapeutics research
JID - 7610364
RN  - 0 (Opioid Peptides)
SB  - IM
MH  - *Acupuncture Therapy
MH  - Animals
MH  - Brain/*drug effects
MH  - Male
MH  - Opioid Peptides/*pharmacology
MH  - Pain/*drug therapy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Nociceptin
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 10.3727/036012996816356852 [doi]
PST - ppublish
SO  - Acupunct Electrother Res. 1996 Jul-Dec;21(3-4):199-205. doi: 
      10.3727/036012996816356852.