PMID- 9052855
OWN - NLM
STAT- MEDLINE
DCOM- 19970521
LR  - 20131121
IS  - 1018-7782 (Print)
IS  - 1018-7782 (Linking)
VI  - 5
IP  - 1
DP  - 1997 Jan-Feb
TI  - Pentoxifylline, cyclosporine A and taurolidine inhibit endotoxin-stimulated tumor 
      necrosis factor-alpha production in rat mesangial cell cultures.
PG  - 100-4
AB  - Tumor necrosis factor-alpha (TNF-alpha) is an important mediator in the 
      pathogenesis of glomerular disease. Intrinsic glomerular cells as well as 
      extraglomerular cells have been found as a source of TNF-alpha. Rat glomerular 
      mesangial cells produce TNF-alpha after stimulation with bacterial 
      lipopolysaccharide (0.1, 1.0 and 10 microg/ml) over different times (4, 8, 16 and 
      24 h). We show that lipopolysaccharide-induced production of TNF-alpha in rat 
      mesangial cell cultures is inhibited by pentoxifylline (50 mg/ml), cyclosporine A 
      (0.1 microg/ml) and taurolidine (100 mg/ml). Inhibition of this production seems 
      to be a promising treatment option for renal disease. Already pentoxifylline and 
      cyclosporine A have been shown to improve different glomerular pathologies. Their 
      in vitro effect on TNF-alpha production shown here might influence this.
FAU - Leithauser, M L
AU  - Leithauser ML
AD  - Department of Internal Medicine, Medical University of Lubeck, Germany.
FAU - Rob, P M
AU  - Rob PM
FAU - Sack, K
AU  - Sack K
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Exp Nephrol
JT  - Experimental nephrology
JID - 9302239
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Endotoxins)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Thiadiazines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vasodilator Agents)
RN  - 1EQV5MLY3D (Taurine)
RN  - 83HN0GTJ6D (Cyclosporine)
RN  - 8OBZ1M4V3V (taurolidine)
RN  - SD6QCT3TSU (Pentoxifylline)
SB  - IM
MH  - Animals
MH  - Anti-Infective Agents/*pharmacology
MH  - Cells, Cultured/drug effects/metabolism
MH  - Cyclosporine/*pharmacology
MH  - Endotoxins/pharmacology
MH  - Glomerular Mesangium/cytology
MH  - Immunosuppressive Agents/*pharmacology
MH  - Lipopolysaccharides/pharmacology
MH  - Male
MH  - Pentoxifylline/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Taurine/*analogs & derivatives/pharmacology
MH  - Thiadiazines/*pharmacology
MH  - Tumor Necrosis Factor-alpha/*biosynthesis/drug effects/metabolism
MH  - Vasodilator Agents/*pharmacology
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
PST - ppublish
SO  - Exp Nephrol. 1997 Jan-Feb;5(1):100-4.