PMID- 9053327
OWN - NLM
STAT- MEDLINE
DCOM- 19970313
LR  - 20220215
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 124
IP  - 2
DP  - 1997 Jan
TI  - Retinoid receptors promote primary neurogenesis in Xenopus.
PG  - 515-23
AB  - Retinoid receptors, which are members of the nuclear hormone receptor 
      superfamily, act as ligand-dependent transcription factors. They mediate the 
      effects of retinoic acid primarily as heterodimers of retinoic acid receptors 
      (RARs) and retinoid X receptors (RXRs). To analyse their function, xRXR beta 
      synthetic mRNA was injected into Xenopus embryos in combination with normal and 
      mutated xRAR alpha transcripts. Two informative phenotypes are reported here. 
      Firstly, over-expression of xRXR beta with xRAR alpha results in the formation of 
      ectopic primary neurons. Secondly, blocking retinoid signalling with a mutated 
      xRAR alpha results in a lack of primary neurons. These two phenotypes, from 
      contra-acting manipulations, indicate a role for retinoid signalling during 
      neurogenesis.
FAU - Sharpe, C R
AU  - Sharpe CR
AD  - Department of Zoology, University of Cambridge, UK.
FAU - Goldstone, K
AU  - Goldstone K
LA  - eng
SI  - GENBANK/X87365
SI  - GENBANK/X87366
PT  - Journal Article
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Retinoic Acid Receptor alpha)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
RN  - 0 (retinoic acid receptor beta)
RN  - EC 2.3.1.28 (Chloramphenicol O-Acetyltransferase)
SB  - IM
MH  - Animals
MH  - Blastocyst/cytology/physiology
MH  - Cell Division
MH  - Chloramphenicol O-Acetyltransferase/biosynthesis
MH  - Embryo, Nonmammalian/*physiology
MH  - Embryonic Induction
MH  - Molecular Sequence Data
MH  - Nervous System/*embryology
MH  - Neurons/cytology/*physiology
MH  - Neurons, Afferent/physiology
MH  - Protein Biosynthesis
MH  - RNA, Messenger/metabolism
MH  - Receptors, Retinoic Acid/biosynthesis/*physiology
MH  - Recombinant Fusion Proteins/biosynthesis
MH  - Retinoic Acid Receptor alpha
MH  - Retinoid X Receptors
MH  - Signal Transduction
MH  - Transcription Factors/biosynthesis/*physiology
MH  - Transcription, Genetic
MH  - Xenopus
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1242/dev.124.2.515 [doi]
PST - ppublish
SO  - Development. 1997 Jan;124(2):515-23. doi: 10.1242/dev.124.2.515.