PMID- 9057189
OWN - NLM
STAT- MEDLINE
DCOM- 19970619
LR  - 20190905
IS  - 0885-3177 (Print)
IS  - 0885-3177 (Linking)
VI  - 14
IP  - 2
DP  - 1997 Mar
TI  - Role of extrinsic innervation in carbohydrate-induced ileal modulation of 
      pancreatic secretion and upper gut function.
PG  - 166-73
AB  - Previously we showed that carbohydrate (CHO) in the ileum slowed gastric emptying 
      and increased pancreatic amylase secretion relative to that of other enzymes. Our 
      aim here was to determine if extrinsic innervation of the jejunoileum 
      participates in the CHO-induced ileal modulation of postprandial upper gut 
      function. Six dogs were studied before and 2-3 weeks after in situ neural 
      isolation of the jejunoileum (complete extrinsic denervation). Gastric emptying 
      (GE) and pancreatic amylase secretion were quantitated for 4 h after a 300-ml 
      meal containing 3H-PEH (liquid marker) and 99mTc sulfur colloid cooked with eggs 
      (solid marker). Coincident with feeding, we started a distal ileal infusion of 
      150 mM NaCl or 40 mg.min-1 CHO. Extrinsic denervation abolished the slowing of GE 
      of liquids and solids and the augmented increase in amylase and trypsin in 
      relation to solid emptying seen in the neurally intact dogs prior to denervation. 
      Denervation also abolished the decrease in total pancreatic exocrine secretion in 
      response to ileal CHO. Increases in plasma concentrations of peptide YY (PYY) 
      were correlated temporally with decreased GE of solids and increased exocrine 
      secretion during ileal CHO in neurally intact dogs, but no increases in PYY 
      release occurred after extrinsic denervation. Extrinsic denervation of the 
      jejunoileum abolished the effect of ileal CHO on GE of liquids and solids, the 
      decrease in total amylase secretion during ileal CHO, and the relative increase 
      in enzyme secretion expressed as total enzyme output per percentage solid marker 
      emptied. Extrinsic innervation of the jejunoileum mediates ileal modulation of GE 
      and the relationship of amylase secretion to GE of solids. The mechanism of this 
      effect may be via neurally mediated release of PYY.
FAU - Sarr, M G
AU  - Sarr MG
AD  - Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA.
FAU - Foley, M K
AU  - Foley MK
FAU - Winters, R C
AU  - Winters RC
FAU - Duenes, J A
AU  - Duenes JA
FAU - DiMagno, E P
AU  - DiMagno EP
LA  - eng
GR  - DK39337/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pancreas
JT  - Pancreas
JID - 8608542
RN  - 0 (Carbohydrates)
RN  - 0 (Peptides)
RN  - 106388-42-5 (Peptide YY)
RN  - 39379-15-2 (Neurotensin)
RN  - EC 3.2.1.- (Amylases)
RN  - EC 3.4.21.4 (Trypsin)
SB  - IM
MH  - Amylases/metabolism
MH  - Animals
MH  - Carbohydrates/*pharmacology
MH  - Denervation
MH  - Dogs
MH  - Female
MH  - Gastric Emptying/*physiology
MH  - Ileum/*innervation/*physiology
MH  - Jejunum/innervation
MH  - Kinetics
MH  - Neurotensin/blood
MH  - Pancreas/*metabolism
MH  - Peptide YY
MH  - Peptides/blood
MH  - Trypsin/metabolism
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - 10.1097/00006676-199703000-00009 [doi]
PST - ppublish
SO  - Pancreas. 1997 Mar;14(2):166-73. doi: 10.1097/00006676-199703000-00009.