PMID- 9057655
OWN - NLM
STAT- MEDLINE
DCOM- 19970401
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 89
IP  - 5
DP  - 1997 Mar 1
TI  - A new subtype of pre-B acute lymphoblastic leukemia with t(5;12)(q31q33;p12), 
      molecularly and cytogenetically distinct from t(5;12) in chronic myelomonocytic 
      leukemia.
PG  - 1716-22
AB  - Translocation t(5;12)(q33;p13), resulting in an ETV6/PDGFRB gene fusion, is a 
      recurrent chromosomal abnormality associated with chronic myelomonocytic leukemia 
      (CMML). An analogous translocation was also found in four cell lines with 
      features of pre-B acute lymphoblastic leukemia (ALL). Using fluorescence in situ 
      hybridization (FISH) we show here that in three of these cell lines identical 
      complex rearrangements occurred. However, the regions involved on 5q and 12p are 
      different from the breakpoints in CMML, and the translocation is accompanied by 
      seemingly identical cryptic deletions of both 5q and 12p chromosome sequences in 
      all analyzed pre-B ALL cell lines. The similar cytogenetic, FISH, and 
      immunophenotyping findings in the three cell lines suggest that the 
      t(5;12)(q31q33;p12) defines a new entity of pre-B ALL.
FAU - Wlodarska, I
AU  - Wlodarska I
AD  - Center for Human Genetics, Flemish Interuniversity, University of Leuven, 
      Belgium.
FAU - Aventin, A
AU  - Aventin A
FAU - Ingles-Esteve, J
AU  - Ingles-Esteve J
FAU - Falzetti, D
AU  - Falzetti D
FAU - Criel, A
AU  - Criel A
FAU - Cassiman, J J
AU  - Cassiman JJ
FAU - Mecucci, C
AU  - Mecucci C
FAU - Van den Berghe, H
AU  - Van den Berghe H
FAU - Marynen, P
AU  - Marynen P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
MH  - Acute Disease
MH  - *Chromosomes, Human, Pair 12
MH  - *Chromosomes, Human, Pair 2
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myelomonocytic, Chronic/*genetics
MH  - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*classification/genetics
MH  - *Translocation, Genetic
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - S0006-4971(20)59157-X [pii]
PST - ppublish
SO  - Blood. 1997 Mar 1;89(5):1716-22.