PMID- 9058500
OWN - NLM
STAT- MEDLINE
DCOM- 19970520
LR  - 20190727
IS  - 0049-3848 (Print)
IS  - 0049-3848 (Linking)
VI  - 85
IP  - 3
DP  - 1997 Feb 1
TI  - Very low doses of unfractionated heparin potentiate the anti-Xa activity of low 
      molecular weight heparin (enoxaparin).
PG  - 259-65
AB  - Some previous reports indicated that a minimal amount of anti-IIa is necessary 
      for the optimal anti-Xa activity of low molecular weight heparin (LMW-H). To know 
      if we could improve the prophylactic activity of LMW-H, providing a mild 
      antithrombin effect, we conducted an experiment in which we administered 
      subcutaneously to 10 volunteers, very low doses of unfractionated heparin (UFH), 
      (1000 IU), a LMW-H (enoxaparin, 2000 IU = 20mg), or both heparins together on 
      alternate days, and measure the anti-Xa activity before, and 4 hours after 
      injection. We found that the anti-Xa activity in the first group (UFH), increased 
      by 33%, over the basal values; in the second group (LMW-H), by 93%, but it 
      increased by 282%, in the third group (UFH + LMW-H) showing clearly (p < 0.0069), 
      that UFH could increase synergistically, more than additive, the anti-Xa activity 
      of enoxaparin. The impact on the cost-effectiveness of antithrombotic prophylaxis 
      and the therapeutic results with the herein combined scheme should be evaluated.
FAU - Perez-Requejo, J L
AU  - Perez-Requejo JL
AD  - Centro Policlinico Valencia, Venezuela.
FAU - Lucena-Solano, O
AU  - Lucena-Solano O
FAU - Perez-Garcia, M
AU  - Perez-Garcia M
FAU - Santarelli, M T
AU  - Santarelli MT
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - 0 (Anticoagulants)
RN  - 0 (Factor Xa Inhibitors)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
EIN - Thromb Res 1997 Jul 15;87(2):269
MH  - Anticoagulants/*pharmacology
MH  - Drug Synergism
MH  - *Factor Xa Inhibitors
MH  - Heparin/*pharmacology
MH  - Heparin, Low-Molecular-Weight/*pharmacology
MH  - Humans
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - S0049-3848(97)00010-8 [pii]
AID - 10.1016/s0049-3848(97)00010-8 [doi]
PST - ppublish
SO  - Thromb Res. 1997 Feb 1;85(3):259-65. doi: 10.1016/s0049-3848(97)00010-8.