PMID- 9058776
OWN - NLM
STAT- MEDLINE
DCOM- 19970408
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 73
IP  - 1-2
DP  - 1997 Mar
TI  - Pentoxifylline down-regulates adhesion molecule expression and inflammatory 
      cytokine production in cultured peripheral blood mononuclear cells from patients 
      with HTLV-I-associated myelopathy.
PG  - 191-6
AB  - To clarify if pentoxifylline (PTX) may have therapeutic potential for human 
      T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM), we 
      investigated the in vitro effect of PTX on spontaneous proliferation of 
      peripheral blood lymphocytes (SPP), as well as on the expression of adhesion 
      molecules, such as lymphocyte function antigen-1 (LFA-1) and very late activation 
      antigen-4 (VLA-4), and the production of inflammatory cytokines, such as tumor 
      necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma) and 
      granulocyte-monocyte colony stimulating factor (GM-CSF), in cultured PBMC from 10 
      HAM patients, compared with control subjects. SPP in HAM patients was 
      significantly suppressed in a dose-dependent manner with PTX. Using flow 
      cytometry, PTX was found to down-regulate the expression of LFA-1 and VLA-4 on 
      CD4+ and CD8+ T cells in HAM patients as well as control subjects. However, the 
      fall in the expression of LFA-1 and VLA-4 on CD4+ T cell population in HAM 
      patients was higher than that of control subjects. PTX caused a significant 
      suppression of spontaneous production of TNF-alpha by cultured PBMC of HAM 
      patients. It also caused a small but significant suppression GM-CSF and IFN-gamma 
      production. Collectively, our results suggest that PTX might be therapeutically 
      effective at critical points in the immunopathogenesis of HAM.
FAU - Tsujino, A
AU  - Tsujino A
AD  - First Department of Internal Medicine, Nagasaki University School of Medicine, 
      Sakamoto, Japan.
FAU - Nakamura, T
AU  - Nakamura T
FAU - Nishiura, Y
AU  - Nishiura Y
FAU - Shirabe, S
AU  - Shirabe S
FAU - Furuya, T
AU  - Furuya T
FAU - Goto, H
AU  - Goto H
FAU - Kawakami, A
AU  - Kawakami A
FAU - Eguchi, K
AU  - Eguchi K
FAU - Nagataki, S
AU  - Nagataki S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (CD4 Antigens)
RN  - 0 (CD8 Antigens)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Cytokines)
RN  - 0 (Phosphodiesterase Inhibitors)
RN  - SD6QCT3TSU (Pentoxifylline)
SB  - IM
MH  - Adult
MH  - Aged
MH  - CD4 Antigens/analysis
MH  - CD8 Antigens/analysis
MH  - Cell Adhesion Molecules/*biosynthesis
MH  - Cell Division/drug effects
MH  - Cells, Cultured
MH  - Cytokines/antagonists & inhibitors
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monocytes/immunology/*metabolism/pathology
MH  - Paraparesis, Tropical Spastic/blood/*metabolism/pathology
MH  - Pentoxifylline/*pharmacology
MH  - Phosphodiesterase Inhibitors/*pharmacology
MH  - Reference Values
EDAT- 1997/03/01 00:00
MHDA- 2000/06/01 09:00
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - S0165-5728(96)00198-1 [pii]
AID - 10.1016/s0165-5728(96)00198-1 [doi]
PST - ppublish
SO  - J Neuroimmunol. 1997 Mar;73(1-2):191-6. doi: 10.1016/s0165-5728(96)00198-1.