PMID- 9060077
OWN - NLM
STAT- MEDLINE
DCOM- 19970530
LR  - 20190905
IS  - 0036-5599 (Print)
IS  - 0036-5599 (Linking)
VI  - 31
IP  - 1
DP  - 1997 Feb
TI  - The expression of receptors for estrogen and epithelial growth factor in the male 
      rabbit prostate and prostatic urethra following castration.
PG  - 15-8
AB  - In the lower urinary tract of the male rabbit, estrogen receptors (ERs) are 
      restricted to the urethra and the prostatic stroma. At present, the function of 
      ERs in these tissues is not known. Epithelial growth factor (EGF) stimulates 
      proliferation of epidermal and epithelial tissues, and several animal studies 
      have indicated that EGF is regulated by estrogen. On this background, we have 
      studied the effect of castration on the expression of ERs and EGF receptors in 
      the rabbit prostatic urethra and prostate. Twelve male rabbits were studied 
      fourteen days after castration, and eight normal rabbits were included as 
      controls. In the control group, ERs were found in the urothelial lining and 
      lamina propria of the prostatic urethra, and in the prostatic stroma. EGF 
      receptors were demonstrated in the epithelial lining of the prostatic urethra and 
      the glandular epithelium of the prostate. Following castration, the expression of 
      ERs, assessed as the increase in the number of positively stained specimens, 
      increased significantly in the lamina propria of the prostatic urethra and the 
      prostatic stroma. EGF receptor expression increased significantly in the 
      epithelial lining of the prostatic urethra. In the prostate, the increase was not 
      significant. The results give no support to the view that ERs play role in the 
      regulation of EGF receptors in the rabbit prostatic urethra nor the prostate.
FAU - Bodker, A
AU  - Bodker A
AD  - Dept. of Urology, Hvidovre Hospital, University of Copenhagen, Denmark.
FAU - Balslev, E
AU  - Balslev E
FAU - Iversen, H G
AU  - Iversen HG
FAU - Meyhoff, H H
AU  - Meyhoff HH
FAU - Andersson, K E
AU  - Andersson KE
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Urol Nephrol
JT  - Scandinavian journal of urology and nephrology
JID - 0114501
RN  - 0 (Receptors, Estrogen)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Animals
MH  - Cell Division/genetics
MH  - Epithelium/pathology
MH  - ErbB Receptors/*genetics
MH  - Gene Expression/physiology
MH  - Immunoenzyme Techniques
MH  - Male
MH  - *Orchiectomy
MH  - Prostate/*pathology
MH  - Rabbits
MH  - Receptors, Estrogen/*genetics
MH  - Urethra/*pathology
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.3109/00365599709070295 [doi]
PST - ppublish
SO  - Scand J Urol Nephrol. 1997 Feb;31(1):15-8. doi: 10.3109/00365599709070295.