PMID- 9060406
OWN - NLM
STAT- MEDLINE
DCOM- 19970522
LR  - 20230320
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 8
IP  - 2
DP  - 1997 Feb
TI  - The mouse Spam1 maps to proximal chromosome 6 and is a candidate for the sperm 
      dysfunction in Rb(6.16)24Lub and Rb(6.15)1Ald heterozygotes.
PG  - 94-7
AB  - We have determined the chromosomal localization of the murine gene encoding the 
      68-kDa sperm adhesion molecule 1, Spam1 or Ph-20. Using two independent 
      approaches, fluorescence in situ hybridization (FISH) and interspecific backcross 
      analysis we show the Spam1 maps to proximal mouse Chromosome (Chr) 6. This map 
      position is within the conserved linkage group corresponding to human Chr 7q, 
      where the human homolog, SPAM 1, has been shown to map previously. Genetic 
      mapping shows the gene to be very closely linked to Met, one of the most proximal 
      loci on MMU 6. It thus places the gene near the centromere and the junction of 
      the Rb(6.16)24Lub and Rb(6.15)1Ald translocations. The essential role of the 
      Spam1 sperm antigen in mouse sperm-egg interactions and its gene location provide 
      strong support for its candidacy as the gene involved in the dysfunction of mouse 
      sperm bearing the Rb(6.16)24Lub or Rb(6.15)1Ald translocation.
FAU - Deng, X
AU  - Deng X
AD  - Department of Biology, University of Delaware, Newark 19716-2590, USA.
FAU - Moran, J
AU  - Moran J
FAU - Copeland, N G
AU  - Copeland NG
FAU - Gilbert, D J
AU  - Gilbert DJ
FAU - Jenkins, N A
AU  - Jenkins NA
FAU - Primakoff, P
AU  - Primakoff P
FAU - Martin-DeLeon, P A
AU  - Martin-DeLeon PA
LA  - eng
SI  - GENBANK/U33958
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DNA, Complementary)
RN  - EC 3.2.1.35 (Hyaluronoglucosaminidase)
RN  - EC 3.2.1.35 (hyaluronidase PH-20)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cell Adhesion Molecules/*genetics
MH  - *Chromosome Mapping
MH  - Chromosomes
MH  - DNA, Complementary
MH  - Female
MH  - Genetic Linkage
MH  - Heterozygote
MH  - Humans
MH  - Hyaluronoglucosaminidase
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - Sperm-Ovum Interactions
MH  - Spermatozoa/*physiology
MH  - Translocation, Genetic
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.1007/s003359900365 [doi]
PST - ppublish
SO  - Mamm Genome. 1997 Feb;8(2):94-7. doi: 10.1007/s003359900365.