PMID- 9061691
OWN - NLM
STAT- MEDLINE
DCOM- 19970613
LR  - 20061115
IS  - 0305-1846 (Print)
IS  - 0305-1846 (Linking)
VI  - 23
IP  - 1
DP  - 1997 Feb
TI  - Nerve growth factor production and expression of p75 by Schwann cells and 
      neurofibroblasts in response to M. leprae infection and macrophage secretory 
      products.
PG  - 59-67
AB  - This study describes the changes occurring in vitro in nerve growth factor (NGF) 
      production and expression of p75 by murine Schwann cells and neurofibroblasts, 
      following infection with Mycobacterium leprae and in the presence of macrophage 
      secretory products, using a semiquantitative ELISA. These parameters are compared 
      in two strains of mice, Swiss White (SW) and C57B1/6, as they differ in their 
      response to M. leprae infection; C57B1/6 is the 'resistant' strain. On infection, 
      NGF levels remained unaltered in Schwann cells from both strains, while 
      fibroblasts from C57B1/6 strain showed an increase in NGF production. Expression 
      of p75 by Schwann cells was decreased on infection in both strains of mice. In 
      vivo, this opposing effect of infection on NGF production and p75 expression by 
      Schwann cells and neurofibroblasts may result in suboptimal amounts of NGF 
      reaching neurons of the affected leprous nerves. Macrophage secretory products 
      suppressed the production of NGF by infected neurofibroblasts from SW strain mice 
      and the expression of p75 in Schwann cells from both strains. These results 
      indicate that macrophages do not assist in nerve repair in leprosy and the 
      differences in response to macrophage secretory products in the two strains 
      suggests that different mechanisms of nerve repair operate in SW and C57B1/6 mice 
      and presumably in lepromatous and tuberculoid patients.
FAU - Singh, N
AU  - Singh N
AD  - Foundation for Medical Research, Worli, Bombay, India.
FAU - Birdi, T J
AU  - Birdi TJ
FAU - Antia, N H
AU  - Antia NH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropathol Appl Neurobiol
JT  - Neuropathology and applied neurobiology
JID - 7609829
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Oncogene Proteins v-fos)
SB  - IM
MH  - Animals
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Fibroblasts/*metabolism
MH  - Leprosy/*metabolism
MH  - Macrophages/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nerve Growth Factors/*metabolism
MH  - Oncogene Proteins v-fos/*metabolism
MH  - Schwann Cells/*metabolism
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
PST - ppublish
SO  - Neuropathol Appl Neurobiol. 1997 Feb;23(1):59-67.