PMID- 90617
OWN - NLM
STAT- MEDLINE
DCOM- 19791218
LR  - 20191210
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 9
IP  - 5
DP  - 1979 May
TI  - Lysolecithin analogs as adjuvants in delayed-type hypersensitivity in mice. I. 
      Characterization of the adjuvant effect.
PG  - 363-6
AB  - The adjuvant activity of 5 different lysolecithin analogs (LLA) has been studied 
      in delayed-type hypersensitivity (DTH) using fowl gamma globulin, bovine serum 
      albumin and the terpolymer L-glutamic acid 60-L-alanine30-L-tyrosine10(GAT), as 
      antigens. Increased DTH responses, by factors of 1.8--2.0 in CBA and BALB/c mice, 
      showed that LLA are immunopotentiators if given intraperitoneally (i.p.) or 
      subcutaneously (s.c.) together with the antigen. The concentration range, within 
      which LLA are active, is limited to 10--20 micrograms/mouse s.c. and 100--300 
      micrograms/mouse i.p. Adjuvanticity was tested as a function of the LLA 
      structure. The most pronounced immunopotentiation was obtained with racemic 
      1-octadecyl-2-methylglycero-3-phosphorylcholine (ET18-O-CH3). The LLA became less 
      active with decreasing numbers of C atoms in the alkyl chain.
FAU - Arnold, B
AU  - Arnold B
FAU - Miller, J F
AU  - Miller JF
FAU - Weltzien, H U
AU  - Weltzien HU
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Antigens)
RN  - 0 (Lysophosphatidylcholines)
RN  - 0 (Peptides)
RN  - 0 (Polymers)
RN  - 0 (gamma-Globulins)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 31325-29-8 (GAT)
SB  - IM
MH  - *Adjuvants, Immunologic
MH  - Animals
MH  - Antigens/administration & dosage
MH  - Female
MH  - *Hypersensitivity, Delayed
MH  - Lysophosphatidylcholines/*pharmacology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Peptides/administration & dosage/immunology
MH  - Polymers
MH  - Serum Albumin, Bovine/administration & dosage
MH  - Structure-Activity Relationship
MH  - gamma-Globulins/administration & dosage
EDAT- 1979/05/01 00:00
MHDA- 1979/05/01 00:01
CRDT- 1979/05/01 00:00
PHST- 1979/05/01 00:00 [pubmed]
PHST- 1979/05/01 00:01 [medline]
PHST- 1979/05/01 00:00 [entrez]
AID - 10.1002/eji.1830090505 [doi]
PST - ppublish
SO  - Eur J Immunol. 1979 May;9(5):363-6. doi: 10.1002/eji.1830090505.