PMID- 9062577 OWN - NLM STAT- MEDLINE DCOM- 19970326 LR - 20190816 IS - 0165-4608 (Print) IS - 0165-4608 (Linking) VI - 93 IP - 1 DP - 1997 Jan TI - Identification of region specific genes by chromosome microdissection. PG - 29-32 AB - Chromosome microdissection is an extremely useful molecular cytogenetic tool for the characterization of chromosomal abnormalities in tumor cells. Although it has been used primarily in conjunction with fluorescence in situ hybridization (FISH), microdissection has also been useful for molecular analysis via microclone library construction. Recently, microdissection has been applied to the isolation of region specific cDNAs with sufficient success that gene discovery can now be added to the list of applications of this versatile molecular cytogenetic technique. FAU - Meltzer, P S AU - Meltzer PS AD - Laboratory of Cancer Genetics, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892-4470, USA. FAU - Guan, X Y AU - Guan XY FAU - Su, Y A AU - Su YA FAU - Gracia, E AU - Gracia E FAU - Trent, J M AU - Trent JM LA - eng PT - Journal Article PL - United States TA - Cancer Genet Cytogenet JT - Cancer genetics and cytogenetics JID - 7909240 RN - 0 (DNA, Complementary) SB - IM MH - Chromosome Mapping/*methods MH - DNA, Complementary/isolation & purification MH - Gene Amplification MH - Humans MH - In Situ Hybridization, Fluorescence/*methods MH - Polymerase Chain Reaction/methods EDAT- 1997/01/01 00:00 MHDA- 1997/01/01 00:01 CRDT- 1997/01/01 00:00 PHST- 1997/01/01 00:00 [pubmed] PHST- 1997/01/01 00:01 [medline] PHST- 1997/01/01 00:00 [entrez] AID - S0165460896002695 [pii] AID - 10.1016/s0165-4608(96)00269-5 [doi] PST - ppublish SO - Cancer Genet Cytogenet. 1997 Jan;93(1):29-32. doi: 10.1016/s0165-4608(96)00269-5.