PMID- 9062745
OWN - NLM
STAT- MEDLINE
DCOM- 19970523
LR  - 20190721
IS  - 0105-1873 (Print)
IS  - 0105-1873 (Linking)
VI  - 36
IP  - 2
DP  - 1997 Feb
TI  - Dinitrohalobenzenes: evaluation of relative skin sensitization potential using 
      the local lymph node assay.
PG  - 97-100
AB  - The dinitrohalobenzenes are known to cause skin sensitization and have been used 
      in many seminal investigations of the relationships between physicochemical 
      characteristics and sensitizing potential. The electrophilic theory of skin 
      sensitization implies that contact allergic potential should correlate positively 
      with ability of chemicals to react with proteins to form immunogenic 
      hapten-protein conjugates. It is intriguing, therefore, that previous studies in 
      guinea pigs and mice have suggested that such correlations do not apply to 
      dinitrohalobenzenes. To address this, we have examined, using the murine local 
      lymph node assay (LLNA), the sensitizing activity of 2,4-dinitrofluorobenzene 
      (DNFB), 2,4-dinitrochlorobenzene (DNCB), 2,4-dinitrobromo-benzene (DNBB) and 
      2,4-dinitroiodobenzene (DNIB). In contrast to previous investigations, it was 
      found that the ability of these chemicals to provoke responses in the LLNA 
      correlated closely with their reported protein reactivity. On the basis of these 
      data, it is proposed that dinitrohalobenzenes conform to the electrophilic theory 
      of skin sensitization and that they should be regarded as direct acting haptens.
FAU - Basketter, D A
AU  - Basketter DA
AD  - Unilever Environmental Safety Laboratory, Sharnbrook, Bedfordshire, UK.
FAU - Dearman, R J
AU  - Dearman RJ
FAU - Hilton, J
AU  - Hilton J
FAU - Kimber, I
AU  - Kimber I
LA  - eng
PT  - Journal Article
PL  - England
TA  - Contact Dermatitis
JT  - Contact dermatitis
JID - 7604950
RN  - 0 (Allergens)
RN  - 0 (Dinitrobenzenes)
SB  - IM
MH  - *Allergens
MH  - Animals
MH  - Dermatitis, Allergic Contact/*diagnosis/etiology
MH  - Dinitrobenzenes/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - Lymph Nodes/*drug effects/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - *Skin Tests
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.1111/j.1600-0536.1997.tb00421.x [doi]
PST - ppublish
SO  - Contact Dermatitis. 1997 Feb;36(2):97-100. doi: 
      10.1111/j.1600-0536.1997.tb00421.x.