PMID- 9064485
OWN - NLM
STAT- MEDLINE
DCOM- 19970318
LR  - 20220410
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 76
IP  - 1
DP  - 1997 Jan
TI  - Clinicopathologic studies of thymic carcinoids in multiple endocrine neoplasia 
      type 1.
PG  - 21-9
AB  - Thymic carcinoid is part of the multiple endocrine neoplasia type 1 (MEN1) 
      syndrome occurring predominantly in male patients who were heavy smokers, 
      presenting most commonly in middle age. In contrast with metastatic midgut 
      carcinoids, MEN1-related thymic carcinoid is not associated with carcinoid 
      syndrome, nor is it associated with Cushing syndrome, in contrast with sporadic 
      thymic carcinoids. Local invasion and metastasis are common. Prognosis is poor 
      because of late detection, lack of effective treatment, and the aggressive nature 
      of the tumor. All patients with thymic carcinoids should be investigated for 
      MEN1, including thorough clinical evaluation and family studies. Anterior 
      mediastinal lesions in MEN1 male patients should be considered thymic carcinoids 
      until proven otherwise. All male MEN1 patients and asymptomatic gene carriers 
      should be warned of the risk of thymic carcinoids and the possible link to 
      smoking. Computed tomography (CT) of the chest is recommended on first screening 
      for MEN1 in male patients more than 25 years of age, followed by yearly chest 
      X-rays and chest CT every 3 years. Prophylactic thymectomy should be carried out 
      during subtotal or total parathyroidectomy on MEN1 patients.
FAU - Teh, B T
AU  - Teh BT
AD  - Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
FAU - McArdle, J
AU  - McArdle J
FAU - Chan, S P
AU  - Chan SP
FAU - Menon, J
AU  - Menon J
FAU - Hartley, L
AU  - Hartley L
FAU - Pullan, P
AU  - Pullan P
FAU - Ho, J
AU  - Ho J
FAU - Khir, A
AU  - Khir A
FAU - Wilkinson, S
AU  - Wilkinson S
FAU - Larsson, C
AU  - Larsson C
FAU - Cameron, D
AU  - Cameron D
FAU - Shepherd, J
AU  - Shepherd J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adult
MH  - Carcinoid Tumor/genetics/*pathology/secondary/therapy
MH  - Cushing Syndrome/pathology
MH  - Follow-Up Studies
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - Malignant Carcinoid Syndrome/pathology
MH  - Mediastinal Neoplasms/genetics/pathology
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/genetics/*pathology
MH  - Neoplasm Invasiveness
MH  - Parathyroidectomy
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Smoking/adverse effects
MH  - Thymectomy
MH  - Thymus Neoplasms/genetics/*pathology/therapy
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1097/00005792-199701000-00002 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 1997 Jan;76(1):21-9. doi: 10.1097/00005792-199701000-00002.