PMID- 9065561
OWN - NLM
STAT- MEDLINE
DCOM- 19970328
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 48
IP  - 3
DP  - 1997 Mar
TI  - Linkage analysis of HLA class II genes in Swedish multiplex families with 
      multiple sclerosis.
PG  - 758-62
AB  - We assessed the influence of human leukocyte antigen (HLA) class II as 
      susceptibility genes in multiple sclerosis (MS) by linkage analysis. Other 
      research groups, who have shown negative results in studies on affected sibling 
      pairs, have questioned the influence of the HLA class II genes, although they 
      confirmed the association of the DR15,DQ6,Dw2 haplotype to MS. In this report, we 
      find a significant lod score (>3) when using a 2-point linkage analysis of 49 
      small Swedish nuclear MS families with at least two affected family members, 
      typed for HLA class II alleles by PCR amplification with sequence-specific 
      primers. We obtained maximum lod scores when we used dominant or intermediate 
      models with low penetrance. We found that the positive effect on the total lod 
      score was not confined to those families carrying the presumed susceptibility 
      HLA-haplotype Dw2. This observation supports the notion of a functional role of 
      the HLA class II molecules themselves in MS. In addition, we observed significant 
      transmission distortion and an intrafamilial association of the MS-associated 
      class II haplotype HLA-Dw2. These results indicate that the HLA class II genes 
      are of clear importance for MS in the studied population.
FAU - Fogdell, A
AU  - Fogdell A
AD  - Department of Bioscience, Karolinska Institute, NOVUM, Huddinge, Sweden.
FAU - Olerup, O
AU  - Olerup O
FAU - Fredrikson, S
AU  - Fredrikson S
FAU - Vrethem, M
AU  - Vrethem M
FAU - Hillert, J
AU  - Hillert J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Disease Susceptibility
MH  - Female
MH  - *Genetic Linkage
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Humans
MH  - Lod Score
MH  - Male
MH  - Multiple Sclerosis/ethnology/*genetics
MH  - Sweden
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - 10.1212/wnl.48.3.758 [doi]
PST - ppublish
SO  - Neurology. 1997 Mar;48(3):758-62. doi: 10.1212/wnl.48.3.758.