PMID- 9067070 OWN - NLM STAT- MEDLINE DCOM- 19970613 LR - 20170214 IS - 0706-7437 (Print) IS - 0706-7437 (Linking) VI - 42 IP - 2 DP - 1997 Mar TI - Acute treatment of bipolar disorder with adjunctive risperidone in outpatients. PG - 196-9 AB - OBJECTIVE: To test the hypothesis that, although typical neuroleptics are commonly used in the treatment of bipolar disorder, newer atypical antipsychotic agents, like risperidone, may be more effective and better-tolerated. METHOD: The effectiveness of risperidone was evaluated in 14 outpatients with bipolar disorder, type I, who received risperidone for 6.4 +/- 2.7 weeks at 2.75 +/- 1.8 mg/day. RESULTS: Nine (64%) patients were much improved based on Clinical Global Impression (CGI) scores, and mean Global Assessment of Functioning (GAF) scores improved from 48.2 +/- 4.9 to 58.8 +/- 7.3 (t = 4.49, P = 0.0006, paired t test). Treatment was well tolerated, and no patient experienced worsening of mood symptoms while receiving risperidone. CONCLUSION: This open series suggests risperidone is beneficial in the treatment of outpatients with bipolar disorder. FAU - Ghaemi, S N AU - Ghaemi SN AD - Center on Neuroscience, George Washington University, Washington, District of Columbia, USA. FAU - Sachs, G S AU - Sachs GS FAU - Baldassano, C F AU - Baldassano CF FAU - Truman, C J AU - Truman CJ LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Can J Psychiatry JT - Canadian journal of psychiatry. Revue canadienne de psychiatrie JID - 7904187 RN - 0 (Antipsychotic Agents) RN - 33CM23913M (Carbamazepine) RN - 614OI1Z5WI (Valproic Acid) RN - 9FN79X2M3F (Lithium) RN - L6UH7ZF8HC (Risperidone) SB - IM MH - Adult MH - Antipsychotic Agents/*administration & dosage MH - Bipolar Disorder/*drug therapy MH - Carbamazepine/administration & dosage MH - Drug Therapy, Combination MH - Female MH - Humans MH - Lithium/administration & dosage MH - Male MH - Middle Aged MH - Psychiatric Status Rating Scales MH - Retrospective Studies MH - Risperidone/*administration & dosage MH - Treatment Outcome MH - Valproic Acid/administration & dosage EDAT- 1997/03/01 00:00 MHDA- 1997/03/01 00:01 CRDT- 1997/03/01 00:00 PHST- 1997/03/01 00:00 [pubmed] PHST- 1997/03/01 00:01 [medline] PHST- 1997/03/01 00:00 [entrez] AID - 10.1177/070674379704200211 [doi] PST - ppublish SO - Can J Psychiatry. 1997 Mar;42(2):196-9. doi: 10.1177/070674379704200211.