PMID- 9067099
OWN - NLM
STAT- MEDLINE
DCOM- 19970522
LR  - 20190909
IS  - 8755-1039 (Print)
IS  - 1097-0339 (Linking)
VI  - 16
IP  - 2
DP  - 1997 Feb
TI  - Cytologic and fluorescence in situ hybridization (FISH) examination of 
      metanephric adenoma.
PG  - 107-11
AB  - Metanephric adenoma is a recently described benign renal neoplasm with 
      distinctive histologic features. The cytologic appearance and fluorescence in 
      situ hybridization (FISH) studies of this tumor have not been described. We 
      present a case from a 48-yr-old woman. Cytologically, the cells were arranged in 
      tight, short papillae and loose sheets. The cells had scant cytoplasma, round 
      monotonous nuclei with fine even chromatin and rare small nucleoli. 
      Immunohistochemistry revealed no reactivity for epithelial membrane antigen 
      (EMA), keratins (AE1/AE3, callus, 34BE12), or carcinoembryonic antigen (CEA). 
      FISH showed a disomic pattern for chromosomes 7, 17, and for the chromosome 3 
      short arm. The differential diagnosis includes Wilms' tumor, renal adenoma, 
      papillary renal cell carcinoma, and metastatic tumors. Both immunohistochemistry 
      and FISH may be of help in distinguishing some of these lesions.
FAU - Renshaw, A A
AU  - Renshaw AA
AD  - Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, 
      Boston, MA 02115, USA.
FAU - Maurici, D
AU  - Maurici D
FAU - Fletcher, J A
AU  - Fletcher JA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
RN  - 0 (Mucin-1)
RN  - 68238-35-7 (Keratins)
SB  - IM
MH  - Adenoma/chemistry/*pathology
MH  - Carcinoma, Papillary/diagnosis
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Keratins/analysis
MH  - Kidney Neoplasms/chemistry/*pathology
MH  - Middle Aged
MH  - Mucin-1/analysis
MH  - Neoplasm Metastasis/diagnosis
MH  - Tomography, X-Ray Computed
MH  - Wilms Tumor/diagnosis
EDAT- 1997/02/01 00:00
MHDA- 2000/06/22 10:00
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 2000/06/22 10:00 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.1002/(SICI)1097-0339(199702)16:2<107::AID-DC2>3.0.CO;2-E [pii]
AID - 10.1002/(sici)1097-0339(199702)16:2<107::aid-dc2>3.0.co;2-e [doi]
PST - ppublish
SO  - Diagn Cytopathol. 1997 Feb;16(2):107-11. doi: 
      10.1002/(sici)1097-0339(199702)16:2<107::aid-dc2>3.0.co;2-e.